Clinical and Experimental Pediatrics
- Volume 46 Issue 10
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- Pages.966-971
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- 2003
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- 2713-4148(eISSN)
Changes of Neutrophil Count in Peripheral Blood of the Neonate with Periventricular Leukomalacia
신생아 백질연화증 환아 말초혈의 중성구 변화
- Lee, Hwan Seok (Department of Pediatrics, College of Medicine, Kyungpook University) ;
- Park, Kyung Pil (Department of Pediatrics, College of Medicine, Kyungpook University) ;
- Kim, Heng Mi (Department of Pediatrics, College of Medicine, Kyungpook University)
- Received : 2003.06.11
- Accepted : 2003.08.07
- Published : 2003.10.15
Abstract
Purpose : It is now well established that infection and inflammation play an important role in the pathogenesis of ischemic brain damage. The loss of neutrophils from systemic circulation is an associated finding in injury mediated by granulocyte. Periventricular leukomalacia(PVL) caused by ischemia is the principal form of brain injury in premature infants. This study was conducted to evaluate whether the low neutrophil count is associated with periventricular leukomalacia(PVL) in premature infants. Methods : Retrospective review of medical records was undertaken. Subjects were premature infants with a birth weight of less than 1,500 gm, admitted to the Neonatal Intensive Care Unit of Kyungpook University Hospital. A complete blood count of peripheral blood was done within the 1st hour of life. Neutropenia was defined as absolute neutrophil count <
목 적 : 조직 손상에 중성구가 관련하는 병변에서 말초혈 중성구 감소가 관찰되고 있다. 이에 저자는 백질연화증 환아의 출생 직후 채혈한 말초혈에서 중성구의 변화를 조사하여 백질연화증 발생에 있어서의 중성구 감소의 유무 및 나아가 백질연화증 발병 기전을 조사하고자 하였다. 방 법 : 1999년 2월부터 3년 동안 체중 1,500 gm 미만인 신생아로 출생 1시간 이내에 말초혈 온혈구계산(complete blood count)을 시행한 환아를 대상으로 하였다. 중성구는 말초혈에서