Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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A Therapeutic Experience of Congenital Bilateral Neuroblastoma

선천성 양측성 신경모세포종의 치료경험 1례

  • Seo, Yeon Kyong (Department of Pediatrics, School of Medicine, Keimyung University) ;
  • Kim, Heung Sik (Department of Pediatrics, School of Medicine, Keimyung University) ;
  • Kwon, Kun Young (Department of Pathology, School of Medicine, Keimyung University) ;
  • Lee, Hee Jung (Department of Radiology, School of Medicine, Keimyung University) ;
  • Koo, Hong Hoe (Department of Pediatrics, School of Medicine, Sungkyunkwan University)
  • 서연경 (계명대학교 의과대학 소아과학교실) ;
  • 김흥식 (계명대학교 의과대학 소아과학교실) ;
  • 권건영 (계명대학교 의과대학 병리과학교실) ;
  • 이희정 (계명대학교 의과대학 진단방사선과학교실) ;
  • 구홍회 (성균관대학교 의과대학 소아과학교실)
  • Received : 2003.08.04
  • Accepted : 2003.10.10
  • Published : 2003.12.15
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Abstract

Neuroblastoma is the most common intraabdominal malignant tumor of childhood, with 40% arising from the adrenal gland. Bilateral adrenal involvement from synchronous development or metastatic spread of tumor is rarely seen in children with neuroblastoma. The patient was born with a spontaneous vaginal delivery. Birth weight was 3,200 g. Fetal ultrasonography showed a left adrenal cystic mass. At two weeks of age, she was admitted due to a massive abdominal distension and tachypnea. Percutaneous ultrasonography guided biopsy of the left adrenal mass was performed. The result of the biopsy was neuroblastoma. Vincristine and cyclophosphamide were administerd intravenously and 450 cGy of irradiation was added. Left adrenalectomy was accomplished and postoperative course was uneventful. The patient received cancer chemotherapy with a combination of carboplatin, ifosfamide and VP-16 and is now being followed up for three months. We have experienced a case of congenital bilateral neuroblastoma and report the case with brief review of related literatures.

저자들은 산전 초음파에서 복부 종괴가 발견되어 관찰 도중 복부 팽만과 호흡 부전이 발생하여 방사선요법과 항암요법으로 치료하였던 양측성 선천성 신경모세포종 1례를 문헌 고찰과 함께 보고하는 바이다. 선천성 양측성 신경모세포종의 경우 임상경과를 잘 관찰하고 치료여부를 결정하여야 할 것으로 생각된다.

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