Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Effect of Ketogenic Diet on the Nitric Oxide of Pilocarpine-induced Status Epilepticus

Pilocarpine으로 유발된 간질중첩증에서 케톤생성 식이요법에 의한 Nitric Oxide의 변화

  • Kim, Tae-Woo (Department of Neurology, Chungnam National University Hospital, Institute for Brain Research, Chungnam National University) ;
  • Kim, Jae-Moon (Department of Neurology, Chungnam National University Hospital, Institute for Brain Research, Chungnam National University) ;
  • Park, Hee-Dong (Department of Neurology, Samsung Medical Center) ;
  • Jung, Ki-Young (Department of Neurology, Samsung Medical Center) ;
  • Kim, Dong-Wook (Department of Pediatrics, Ilsan Paik Hospital)
  • 김태우 (충남대학교병원 신경과, 충남대학교 뇌연구소) ;
  • 김재문 (충남대학교병원 신경과, 충남대학교 뇌연구소) ;
  • 박희동 (삼성의료원 신경과) ;
  • 정기영 (삼성의료원 신경과) ;
  • 김동욱 (일산백병원 소아과)
  • Published : 2003.12.30
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Abstract

Backgrounds and Objectives: Despite of enormous clinical and laboratory researches focused on the useful markers in status epilepticus(SE), clinically applicable methods are not yet available. Although ketogenic diet (KD) is an old method of treating epilepsies, its outstanding antiepileptic effect in some epileptic patients needs re-evaluation of this methods. This study was performed to evaluate the effect of KD on the change of nitric oxide(NO) during the SE. Methods: After the determination of critical EEG stages in the pilocarpine-induced SE model, serum NO levels were measured with Griess reaction. Open cardiac puncture was done immediately after the four different EEG stages of SE in the KD rats and regular diet (RD) rats. Cessation of SE was done with the 10~20 mg/Kg of diazepam i.p. injection in each stages of SE in KD and RD rats. Results: Pilocarpine-induced SE showed reliable EEG and behavioral patterns in all rats. Also, KD did not affect the SE induced by pilocarpine in terms of the SE induction time and SE severity. Serum NO was consistently higher in KD rats than RD rats in all SE stages. Conclusions: KD significantly increases NO during the pilocarpine-induced SE. These finding might contribute the neuroprotective effect of KD in the SE.

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