Journal of Acupuncture Research
- Volume 20 Issue 3
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- Pages.45-62
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- 2003
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
Induction of the Growth Inhibition and Apoptosis by Beevenom in Human Breast Carcinoma MCF-7 Cells
봉독약침액(蜂毒藥鍼液)에 의한 인체유방암세포(人體乳房癌細胞)의 성장억제(成長抑制) 및 세포사(細胞死)에 관한 연구(硏究)
- Yeo, Sung-won (College of Oriental Medicine, Dong-Eui University) ;
- Seo, Jung-chul (College of Oriental Medicine, Kyung-San University) ;
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Choi, Yung-hyun
(College of Oriental Medicine, Dong-Eui University) ;
- Jang, Kyung-jeon (College of Oriental Medicine, Dong-Eui University)
- Received : 2003.03.26
- Accepted : 2003.05.17
- Published : 2003.06.20
Abstract
Objective : To examine the effects of Beevenom on the cell proliferation of human breast carcinoma cell line MCF-7, we performed various experiments such as does-dependent effect of Beevenom on cell proliferation and viability, morphological changes, and alterations of apoptosis/cell cycle-regulatory gene products. Methods : Beevenom induced cell viability and proliferation of MCF-7 cells in a concentration-dependent manner. The anti-proliferative effect by Beevenom treatment in MCF-7 cells was associated with morphological changes such as membrance shrinking and cell rounding up. Results : Beevenom induced apoptotic cell death in a concentration-dependent manager, which was associated with degradation of