인삼섭취와 암발생과의 관련성에 관한 연구 - 강화코호트연구 -

A Study on the Association Between Ginseng Intake and Incidences of Cancer - Kangwha Cohort Study -

  • 변주선 (연세대학교 대학원 보건학과) ;
  • 오희철 (연세대학교 의과대학 예방의학교실) ;
  • 홍재석 (연세대학교 의과대학 예방의학교실) ;
  • 손태용 (유한대학교 의무행정과) ;
  • 이상욱 (관동대학교 의과대학 예방의학교실)
  • Byun, Joo-Sun (Department of Public Health, Graduate School, Yonsei University) ;
  • Ohrr, Hee-Choul (Department of Preventive Medicine and Public Health, Yonsei University College of Medicine) ;
  • Hong, Jae-Suk (Department of Preventive Medicine and Public Health, Yonsei University College of Medicine) ;
  • Sohn, Tae-Yong (Department of Health Service Administration, Yuhan Junior College) ;
  • Yi, Sang-Wook (Department of Preventive Medicine and Public Health, Kwandong University College of Medicine)
  • 발행 : 2003.12.01

초록

Objectives : There are many concerns about ginseng as a cancer chemopreventive substance, but there have been few epidemiological studies on ginseng, This study sought to examine the relationships between ginseng intake and cancer incidence in the Kangwha cohort. Methods ; Between March 1985 and December 1999, 2697 males, aged 55 or over, as of 1985, were followed up for their cancer incidence. The cancer incidence rate, standardized incidence ratio and risk ratios were calculated according to ginseng intake. A Cox proportional hazard model was used to adjust for age at entry, smoking, alcohol intake, hypertension, and body mass index. Results & Conclusions : The ginseng intake group had the same cancer (C00-C97) incidences (Standardized Incidence Ratio: SIR=1.11, 95% Confidence Interval=0.97-1.27) and the same risk ratio (RR=1.09, 95% Confidence Interval=0.85-1.41) as the no-intake group. Analyzing the subjects that had followed up from 1990, however, the ginseng intake group had lower cancer incidences at all sites (RR=0.79, 95% Confidence Interval=0.58-1.09). This was a cohort study to try and evaluate the association between ginseng intake and the incidences of cancer, The results of this study provide no clear conclusions on the cancer preventive effects of ginseng. Therefore, further study is needed in the future.

키워드

참고문헌

  1. Nam KY. Clinical applications and efficacy of Korean ginseng. J Ginseng Res 2002; 26(3):111-131 (Korean) https://doi.org/10.5142/JGR.2002.26.3.111
  2. Katano M, Yamamoto H, Matsunaga H. Antitumor substance from korea red ginseng power. Pro Abs 5th IntI. Ginseng Symposium, 1988
  3. Soldati F. Immunological studies of ginseng. Pro Abs 5th IntI. Ginseng Symposium, 1988
  4. 황우익. 홍삼과 수종식품 및 생약제중 지용성 생분의 항암성 비교. 한국담배인삼공사, 1994
  5. Shin EK, Park HW, KimSC, Jung NP. The effect of ginseng components on the signal trasduction in the activation of murine macrophages. J Ginseng Res 1996;20(2): 159-167 (Korean)
  6. 최상운. 생쥐 대식세포의 종양세포 치사활성에 미치는 인삼분획불과 지방다당류의영향. 연세대학교 대학원 석사학위논문, 1989
  7. 전혜경. 생쥐의 대식세포 종양치사활성과 항암효과에 미치는 인삼분획물과 Cyclophosphamide의 영향 연세대학교 대학원 석사학위논문, 1991
  8. Wu XG, Zhu DH. Influence of ginseng upon the development of liver cancer induced by diethylnitrosamine in rats. J Tongji Med Univ1990; 10(3): 141-145 https://doi.org/10.1007/BF02986451
  9. Kim JP, Park JG, Lee MD, Han MD, Park ST, Lee BH, Jung SE. Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N' -nitro-N-nitrosoguanidine in rats. Jpn J Surg 1985; 15(6): 427-437 https://doi.org/10.1007/BF02470087
  10. Chen X, Lee TJ. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavemosum. Br J Pharmacol 1995; 115: 15-18 https://doi.org/10.1111/j.1476-5381.1995.tb16313.x
  11. Donati L, Woo IK, Nakamura Y. Effect of korea ginseng on the growth rate of cells. Adv Patol Clin Tumori 1966; 8: 53
  12. 김진복.위암환자에게 인삼투여가수술후영양상태 및 면역기능에 미치는 영향. 한국인 삼연초연구소 보고서, 1992
  13. Yun TK, Choi SY. A case-control study of ginseng intake and cancer. Int J Epidemiol 1990; 19(4): 871-876 https://doi.org/10.1093/ije/19.4.871
  14. Yun TK, Choi SY. Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev 1995; 4(4): 401-408
  15. Yun TK, Choi SY. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int J Epidemiol 1998; 27(3): 359-364 https://doi.org/10.1093/ije/27.3.359
  16. Ohrr H, Nam lM, Lee SH. A Cohort study on the relationship between pesticide use and mortality, and cancer mortality. Korean J Prev Med 1991; 24(3): 390-399 (Korean)
  17. Ohrr H, Kim HO, Kand HG, Sun I. Kangwha county, Korea. In Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J. Cancer incidence in five continents Volume VII. Lyon. IARC Scientific Publications 1997; 143:406-9
  18. Rothman KJ, Greenland S. Modern Epidemiology, 2nd ed. 1998. Lippincott Williams & Wilkins, Philadelphia
  19. Breslow NE, Day NE. Statistical Methods in Cancer Research, Vol. II: The Design and Analysis of Cohort Studies. 1987 International Agency for Research on Cancer, Lyon, France
  20. Yun TK, Kim SH, Inhibition of develpment of benzo(a)pyrene-induced mouse pulmonary adenoma by natural products medium-term bioassay system. J Korea Cancer Assoc 1988; 20: 133-142(Korean)
  21. Yun TK, Kim SH, Lee YS. Trial of a new medium-term model using benzo(a)pyrene induced lung tumor in newborn mice. Anticancer Res 1995; 15(3): 839-845
  22. Yun TK. Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng CA. Meyer. Nutr Rev 1996; 54(11 Pt 2): S71-581
  23. Shin HR, Kim JY, Lee DH, Yun TK, Morgan G, Vainio H. The Cancer-preventive Potential of Panax ginseng: A Review of Human and Experimental Evidence. Korean J Prev Med 2000; 33(4); 383-392 (Korean)
  24. Kakizoe T. Asian studies of cancer chemoprevention: latest clinical results. Eur J Cancer 2000; 36(10); 1303-1309
  25. Cha Rl, Zeng DW, Chang QS. Nonsurgical treatment of small cell lung cancer with chemo-radio-immunotherapy and traditional chinese medicine. Zhonghua Nei Ke ZaZhi 1994; 33(7): 462-466
  26. Han MQ, Liu rx, Gao H. Effects of 24 chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell. Zhongguo Zhong Xi Yi Jie He ZaZhi 1995; 15(3): 147-149
  27. Lin SY, Liu LM, Wu LC. Effects of shenmai injection on immune function in stomach cancer patients after chemotherapy. Zhongguo Zhong Xi Yi lie He Za Zhi 1995; 15(8): 451-3
  28. Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto T. The effect of a traditional Chinese prescription for a case of lung carcinoma. J Altern Complement Med 2000; 6(6): 557-559 https://doi.org/10.1089/acm.2000.6.557