한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제20권4호
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  • Pages.324-331
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  • 2003
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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염 추출법에 의한 폴리락틱산 다공성 지지체 가공

Preparation of Poly(lactic acid) Scaffolds by the Particulate Leaching

  • 이지혜 (기능성 고분자 신소재 연구센터) ;
  • 이종록 (기능성 고분자 신소재 연구센터) ;
  • 강호종 (단국대학교 공과대학 고분자공학과)
  • 발행 : 2003.12.31
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초록

Particulate leaching method for the preparation of porous PLLA scaffolds was carried out and especially, the effect of PLLA/$CHCl_3$ solution concentration on the salt leaching rate and the pore structure of PLLA scaffolds were considered. It was found that maintaining lower PLLA/$CHCl_3$ concentration and higher $CHCl_3$ evaporation temperature in the preparation of PLLA/NaCl mixtures resulted in the enhancement of salt leaching rat e and higher porosity. This is understood that those conditions could minimize the formation of dense PLLA layer on the surface of PLLA/NaCl mixture as well as introducing better porosity on the surface. Higher salt leaching temperature accelerated the salt leaching rate but it seems that there is no influence on the porosity of PLLA scaffolds.

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참고문헌

  1. D. W. Hutmacher, Biotechnology, 12, 689 (1994) https://doi.org/10.1038/nbt0794-689
  2. R. Langer and J. P. Vacanti, Science, 260, 920 (1993) https://doi.org/10.1126/science.8493529
  3. L. G. Cima, J. P.Vacanti, D. Ingber, D. Mooney, and R. Langer, J. Biomech. Eng., 113, 143 (1991) https://doi.org/10.1115/1.2891228
  4. D. L. Wise, 'Biopolymeric Controlled System', Vol. 1, CRS Press, Boca Raton, Ch. 8 (1985)
  5. A. G. Mikos, Y. Bae, L. G. Cima, D. Ingber, J. P. Vacanti, and R. Langer, J. Biomed. Mater. Res., 27, 183 (1993) https://doi.org/10.1002/jbm.820270207
  6. S. Gogolewski and A. J. Pennings, Colloid Polrm. Sci., 261, 477 (1983) https://doi.org/10.1007/BF01419831
  7. A. G. Mikos, A. J. Sarakinos, S. M. Leite, J. P. Vacanti, and R. Langer, Biomaterials, 14, 323 (1993) https://doi.org/10.1016/0142-9612(93)90049-8
  8. A. G. Mikos, A. J. Thorsen, L. A. Czerwonka, Y. Bae, R. Langer, D. N. Winslow, and J. P. Vacanti, polymer, 35, 1068 (1994) https://doi.org/10.1016/0032-3861(94)90953-9
  9. L. E. Freed, J. C. Marquis, A. Nohria, J. Emmanual, A. Mikos, and R. Langer, J. Biomed. Mater. Res., 11, 27 (1993)
  10. Y. S. Nam and T. G. Park, Biomaterials, 20, 1783 (1999) https://doi.org/10.1016/S0142-9612(99)00073-3
  11. L. D. Harris, B. S. Kim, and D. J. Mooney, J. Biomed. Mater. Res., 42, 396 (1998) https://doi.org/10.1002/(SICI)1097-4636(19981205)42:3<396::AID-JBM7>3.0.CO;2-E
  12. K. Whang, C. H. Tomas, K. E. Healy, and G. Nuber, Polymer, 36, 837 (1995) https://doi.org/10.1016/0032-3861(95)93115-3
  13. K. P. Andriano, Y. Tabata, Y. Ikada, and Y. Heller, J. Biomed. Mater. Res., 48, 602 (1999) https://doi.org/10.1002/(SICI)1097-4636(1999)48:5<602::AID-JBM3>3.0.CO;2-6
  14. A. Park, B. Wu, and L. G. Griffith, J. Biomater. Sci. Polym. Ed., 9, 89 (1998) https://doi.org/10.1163/156856298X00451
  15. D. J. Mooney, D. F. Baldwin, N. P. Suh, J. P. Vacanto, and R. Langer, Biomaterials, 17, 1417 (1996) https://doi.org/10.1016/0142-9612(96)87284-X
  16. R. C. Thomson, M. J. Yaszemski, J. M. Powers, and A. G. Mikos, J. Biomater Sci. Polym. Ed., 7, 23 (1995) https://doi.org/10.1163/156856295X00805
  17. Y. S. Nam, J. J. Yoon, and T. G. Park, J. Biomed. Mater. Res., 53, 1 (2000) https://doi.org/10.1002/(SICI)1097-4636(2000)53:1<1::AID-JBM1>3.0.CO;2-R