Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Epitope specificity of Porphyromonas gingivalis heat shock protein for T-cell and/or B-cell in human atherosclerosis

동맥경화증에서 T-세포 및 B-세포에 대한 Porphyromonas gingivalis 열충격 단백의 항원 결정 부위 특이성 연구

  • Bak, Jung-Gyu (Department of Periodontology, College of Dentistry, Pusan National University) ;
  • Kim, Sung-Jo (Department of Periodontology, College of Dentistry, Pusan National University) ;
  • Choi, Jeom-Il (Department of Periodontology, College of Dentistry, Pusan National University)
  • 박정규 (부산대학교 치과대학 치주과학교실) ;
  • 김성조 (부산대학교 치과대학 치주과학교실) ;
  • 최점일 (부산대학교 치과대학 치주과학교실)
  • Published : 2003.06.30
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Abstract

Since periodontal infections are suggested as risk factors for the development of cardiovascular diseases, the present study was performed to evaluate the T cell immune responses specific to Pophylomonas gingivalis(P. gingivalis) heat shock protein(hsp) 60 and T-cell and B-cell epitope specificities for P. gingivalis hsp60 in atherosclerosis. Anti-P, gingivalis IgG antibody titers were elevated in all patients. We could establish P. gingivalis hsp-specific T cell lines from the atheroma lesions, a mixture of $CD4^+$ and $CD8^+$ cells producing the cytokines characteristic of both Th1 and Th2 subsets. of 108 overlapping synthetic peptides spanning whole P. gingivalis hsp60 molecule, ten peptides with common epitopes specificities for both T-cell and B-cell were identified. it was concluded that P. gingivalis hsp60 might K involved in the immunoregulatory process of atherosclerotic diseases with epitope specificities.

Keywords

References

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