생태와환경 (Korean Journal of Ecology and Environment)

한국수생태학회 (The Korean Society of Limnology)
권호 표지

어류를 이용한 내분비계 장애물질 검출 및 Biomarker로서 Vitellogenin의 이용

Detection of Endocrine-Disrupting Chemicals in Fish and the Use of Fish Vitellogenin as a Biomarker

  • 윤석주 (한양대학교 자연과학연구소) ;
  • 김일찬 (한양대학교 의과대학 생화학교실) ;
  • 윤용달 (한양대학교 자연과학대학 생명과학과) ;
  • 이재성 (한양대학교 대학원 환경과학과)
  • Yoon, Seok-Joo (The Research Institute for Natural Sciences, Hanyang University) ;
  • Kim, Il-Chan (Department of Biochemistry, College of Medicine, Hanyang University) ;
  • Yoon, Yong-Dal (Department of Life Science, College of Natural Sciences, Hanyang University) ;
  • Lee, Jae-Seong (Department of Environmental Science, Graduate School, Hanyang University)
  • 발행 : 2003.06.30
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초록

어류 vitellogenin은 난황전구체로 난형성과정동안에 estradiol의 체내 순환에 의해 암컷의 간에서 생산되며 alkylphenol류와 같은 비이온성 계면활성제 등의 내분비계 장애물질에 의해 수컷에서도 생산된다. 물 환경의주요 생물종인 어류는 내분비계장애물질에 의해 암컷에서는 번식률 저하와 함께 수컷에서는 정소의 축소 및 이에 따른 암컷화가 관찰된다. 특히 수컷에서 내분비계 장애물질에 의해 유도된 vitellogenin의 생성을 이용하여 환경오염에 의해 유도된 생물체의 유전자 발현 변화 뿐만 아니라 이를 토대로 특정지역의 환경오염을 모니터링할 수 있다. 본 논문에서는 어류의 vitetlogenin를 이용하여 수환경의 내분비계장애물질의 검출과 환경오염모니터링을 위한 biomarker로서의 유용성을 검토하였다.

Fish vitellogenin produces in female liver during oogensesis through estradiol cycle, and produces even in male liver by endocrine-disrupting chemicals (EDCs) such as alkylphenols. The resulting effects of EDCs lead to the low fecundity of female and the feminization (eg. shrinkage of testis) in male. Especially, the production of vitellogenin in male indicates the environmental contamination of EDCs, resulting in the modulation of gene expression profiles and the monitoring of environmental contamination at specific area. In this paper, we suggest that fish vitellogenin is useful for biomonitoring for environmental contamination and would be substantially useful as a biomarker for a detection of EDCs in aquatic environment.

키워드

참고문헌

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