Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Anticancer & Inhitory Effects of Somamsan

소암산의 항암효과 및 혈관신생억제에 미치는 영향

  • Kim Yoong Su (Departments of Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Seong Won (Departments of Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choo Young Kug (Division of Biology Science, College of Natural Science, Wonkwang University) ;
  • Jung Kyu Yong (Department of Pharmacology, School of Medicine, Wonkwang University) ;
  • Ahn Seong Hun (Departments of Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jeong Woo Yeal (Department of Pathology, College of Oriental Medicine, School of Medicine, Wonkwang University) ;
  • Woo Won Hong (Departments of Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김용수 (원광대학교 한의학 전문대학원) ;
  • 이성원 (원광대학교 한의학 전문대학원) ;
  • 추영국 (원광대학교 자연과학대학 생물학교실) ;
  • 정규용 (원광대학교 의과대학 약리학교실) ;
  • 안성훈 (원광대학교 한의학 전문대학원) ;
  • 정우열 (원광대학교 한의과대학 한방병리학교실) ;
  • 우원홍 (원광대학교 한의학 전문대학원)
  • Published : 2003.02.01
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Abstract

Cancer, which is expressed in various forms, is one of the leading causes of human death, Soamsan (SAS) is composed of ten medicinal herb, the prescription was made according to the principles of Oriental traditional medicine based on the concept of synergic effects and interaction of among the components. SAS has been used for the cancer therapy, but the mechanism of it's effect is not well known. In the present study, the cytotoxic effect of the SAS water extract on cancer cell lines was investigated by the method of MTT in A549 cell lines and the anti-angiogenic effect was shown in the assay of chorioallantoic membrane (CAM) and in the cornea of rat administerd orally with SAS water extraction. The viability of A549 cell lines was not affected by the whole extract of SAS but the n-Hexan fraction of SAS water extract showed strong cytotoxicity which was not seemed to be done by the apoptotic mechanism. SAS water extract showed inhibition effects of angiogenesis induced in the cornea of rat and CAM assay. As the above results, it is suggested that SAS can be a candidate for new prescription for cancer therapy.

Keywords

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