Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Antitumor Activity of Kamibojungikgi-tang

가미보중익기탕이 항암활성 및 항전이효과에 관한 연구

  • Lee Byung Ju (Department of Oriental Medical College, Taejon University) ;
  • Kim Dong Hee (Department of Oriental Medical College, Taejon University) ;
  • Lee Hyo Jeong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
  • 이병주 (대전대학교 한의과대학) ;
  • 김동희 (대전대학교 한의과대학) ;
  • 이효정 (경희대학교 동서의학대학원 동서종양학과) ;
  • 김성훈 (경희대학교 동서의학대학원 동서종양학과)
  • Published : 2003.06.01
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Abstract

To explore the possible cancer agent from oriental prescriptions, we have examined its antitumor and anti metastatic activities of Kamibojungikgi-tang(KBIT). KBIT extracts exhibited cytotoxicity against P388, A549 and B16-F10 cell lines in a dose-dependent manner and showed antiadhesive effect of A549 cell to complex extracellular matrix at 1 ㎎/㎖ in vitro. In DNA topoisomerase I assay, KBIT extracts showed strong inhibitoty effect in a dose-dependent manner. In pulmonary colonization assay with B16BL6, a number of colonies in the lungs were decreased effectively in KBIT treated group as compared with control group. Moreover, in CAM assay, KBIT extracts significantly inhibited angiogenesis at 15㎍/egg as compared with control. The T/C% was 141% in KBIT treated group in S-180 bearing ICR mice. From the above results it was concluded that KBIT had antitumor and anti metastatic activities. So it is expected to be clinically helpful on the prevention and treatment of cancer, although it is still necessary to study its mechanism on molecular biology and immunology.

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