Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Fructus Rubi on the isolated rat aorta

복분자가 백서의 적출동맥에 미치는 영향

  • Sun Sung Gyu (Department of Pharmacology, College of Oriental Medicine, Wonkwang University) ;
  • Oh Kwang Soo (Department of Pharmacology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Nam Soon (Department of Pharmacology, College of Oriental Medicine, Wonkwang University) ;
  • So Eung Hyang (Department of Pharmacology, College of Oriental Medicine, Wonkwang University) ;
  • Hang Jong Hyun (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
  • 선성규 (원광대학교 한의과대학 약리학교실) ;
  • 오광수 (원광대학교 한의과대학 약리학교실) ;
  • 김남순 (원광대학교 한의과대학 약리학교실) ;
  • 소응향 (원광대학교 한의과대학 약리학교실) ;
  • 한종현 (원광대학교 한의과대학 약리학교실)
  • Published : 2003.10.01
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Abstract

This study is to determine the effect of Fructus Rubi to the phenylehrine (PE) induced contraction of isolated rat aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. Contractions evoked by PE 0.1 μM and KCI 65.4 mM were decreased significantly by Fructus Rubi. L-NNA, ODQ, indomethacin and atropine significantly altered the effect of Fructus Rubi, but propranolol did not change the relaxation of Fructus Rubi. These results indicate that Fructus Rubi can relax EP and KCI induced contraction of isolated rat aorta and that this decreasing contraction related to epithelium, nitric oxide, and parasympathetics.

Keywords

References

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