Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory effects of the Juglans sinensis Walnut Ethanol Extract on Carbon Tetrachloride-induced hepatic fibrosis in Rats

호두인 에탄올 추출물의 사고화탄소 유도 간섬유화 억제 효과

  • Jang Seong Il (Department of Immunology, Institute of Immunopia) ;
  • Lim Chang Kyung (Department of Oriental Medical Prescription, Wonkwang University) ;
  • Ryu Jin Duk (Department of Oriental Medical Prescription, Wonkwang University) ;
  • Kim Hui Soo (Department of Oriental Medical Prescription, Wonkwang University) ;
  • Yun Yong Gab (Department of Oriental Medical Prescription, Wonkwang University)
  • 장선일 (임뮤노피아 부설연구소) ;
  • 임창경 (원광대학교 한의과대학 방제학교실) ;
  • 유진덕 (원광대학교 한의과대학 방제학교실) ;
  • 김희수 (원광대학교 한의과대학 방제학교실) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실)
  • Published : 2003.10.01
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Abstract

The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.

Keywords

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