Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Experimental Effects of Taklidanggui-tang on the Anti-Cancer and Immuno-Action

탁리당귀탕이 항암 및 면역작용에 미치는 실험적 효과

  • Park In Su (Department of Gynecology, College of Oriental Medicine, Dongshin University) ;
  • Yang Seung Joung (Department of Gynecology, College of Oriental Medicine, Dongshin University) ;
  • Cho Seong Hee (Department of Gynecology, College of Oriental Medicine, Dongshin University) ;
  • Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Jin Cheon Sik (Department of Gynecology, College of Oriental Medicine, Dongshin University)
  • 박인수 (동신대학교 한의과대학 부인과학교실) ;
  • 양승정 (동신대학교 한의과대학 부인과학교실) ;
  • 조성희 (동신대학교 한의과대학 부인과학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실) ;
  • 진천식 (동신대학교 한의과대학 부인과학교실)
  • Published : 2003.12.01
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Abstract

Taklidanggui-tang was a drug that treated carbuncle and cellulitis. So, the purpose of this Study was to investigate effect of Taklidanggui-tang on the anti-cancer and proliferation of immunocytes, nitric oxide(NO) production of peritoneal macrophages. We used Taklidanggui-tang extract(TDT) with freeze-dried, 8wks-old male mice, and L1210 cell lines for this Study. The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results of this Study were obtained as follow ; TDT was showed cytotoxicity on the L1210 cell lines, increased significantly proliferation of thymocytes and splenocytes in vitro. TDT inhibited significantly proliferation of L1210 cells, increased significantly proliferation of immunocytes in L 1210 cells transplanted mice. And TDT was extended significantly mean survival days in 5-180 cells transplanted mice, but TDT did not increased NO production from peritoneal microphages in L1210 cells transplanted mice. This results suggest that TDT has anti-cancer and immuno-action.

Keywords

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