Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
권호 표지

General Pharmacological Action of Prophylactic Bioactive Materials

예방의학적 생리활성물질의 일반약리작용

  • Published : 2003.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

In the study of general pharmacological action, we tested effect on spontaneous momentum, phenobarbital sleeping times, secretion of gastric juice, body temperature and movement of small intestine, etc. Using Pleurospermum kamtschaticum, Angelica tenuissima, Angelica gigas and Zanthoxylum schinifolium as samples to estimate adverse effects. In the study of general pharmacological action to estimate adverse effects, we observed no side effects of sample-treated groups against the control group.

누룩치, 고본, 당귀 및 산초의 ethanol ext.는 자발운동량에 미치는 영향에 대한 시험에서 아무런 영향을 미치지 않았다. 다만 phenobarbital sodium 수면시간에 대해서는 산초투여군에서만 다소 단축시켰다. 0.7% acetic acid의 복강내 투여에 의해 유발된 writhing syndrome을 다소 억제하였으나 유의성은 없었다. 체온에 미치는 영향에 대한 시험에서는 유의성 있는 체온 변화가 없었다. 다만 흰쥐의 위액분비에 미치는 영향에 대한 시험에서는 누룩치와 고본투여군에서 위액분비량과 총산도가 유의적으로 감소하였다. 소장운동능에 미치는 영향에 대한 시험결과 누룩치, 당귀 및 고본투여군에서 유의성 있는 charoal의 이동억제가 관찰되었다. 결론적으로 누룩치, 고본, 당귀 및 산초의 ethanol ext.는 일반약리작용에 대하여 특이한 작용이 없었다.

Keywords

References

  1. Sipes, I.G. and Grandolfi, A.J.: Biotransformation of Toxicants, Toxicology: The Basic Sciences of Poisons, ed. by M. O., Klassen, M. O. Amdur, and J. Doull, New York, Pergamon Press (1991)
  2. 北川淸雄 독성학, 남강당(1982)
  3. 육창수 한국 본초학, 동명사(1984)
  4. 유상영,: 한 대석 본초학, 동명사(1962)
  5. 황도연: 증맥방약학편 : 남산당 149(1989)
  6. 박영신, 윤경환, 박명철, 김현옥, 김중정: 가정동의대전, 동의과학원, 여강출판사(1993)
  7. Yasuhisa, S., Masako, O., Akira, U., Mitsuo, U. and Seigo, F.: Gas chromatographical studies on natural volatile oils. VIII. on the essential oils of chinese medicines 'Gaoben', Yakugaku zasshi, 90(3), 344 (1970) https://doi.org/10.1248/yakushi1947.90.3_344
  8. Dunham, N.W., Miya, T.S. and Edwards, C.D.: Pharmacological activity of a series of basic esters mono- and dialkyl malonic acid. J. Am. Pharm. Assoc., 46, 208-209 (1957) https://doi.org/10.1002/jps.3030460322
  9. Kato, H., Susuki, S., Nako, K, Lee, E.B. and Takagi, K.: Vasodilating effect of crude latycodin in anesthetized dog. Jap. J. Pharmacol., 23, 709-716. (1973) https://doi.org/10.1254/jjp.23.709
  10. Koster, R., Andersom, M. and de Beer, E.J.: Acetic acid for analgesic screening. Fed. Proc., 18, 412-418 (1959)
  11. Shay, H., Sim, D.C. and Gruenstein, M.: A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterol., 26, 906-913 (1954)
  12. Takagi, K. and Lee, E.B.: Pharmacological studies on Platycodon grandiflorum A. DC. III: Activities of crude platycodin on respiratory and circulatory systems and its other pharmacological activities. Yakugaku Zasshi, 92, 969-973 (1972) https://doi.org/10.1248/yakushi1947.92.8_969
  13. Takemori, A.E., Kupferbcrg, H.T. and Miller, J.W.: Quantitative studies of antagonism of morphine by nalorphine and naloxone. J. Pharmacol. Exp. Ther., 169, 39-45 (1969)
  14. 日本製藥工業協會 醫藥品評價委員會 一般藥理評價法, 1-36 (1993)
  15. 이은방, 천선아, 김상미, 김경란, 김수웅, 이승룡, 이승목, 정훈, 현익상, 이준우, 한만덕: 영지의 단백다당체 G009의 일반약리작용. 응용약물학회지, 2, 369-375 (1994)
  16. 상해과학기술출판사 소학관편 : 중약대사전, (주)소학관, 동경 (1985)
  17. Shay, H., Komarov, S.A., Fels, S.S.: Merance, D., Gruenstein, M.: and Siplet, H.: A simple method for the uniform production of Gastric ulceration in the rats, Gastroenterology, 5, 43 (1945)
  18. Irwin, S.: Comprehensive observational assessment: A systemic, quantiative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologica, 13, 222-257 (1968) https://doi.org/10.1007/BF00401402
  19. Araki, Y. and Ueki, S.: Changes in sensitivity to convulsion in mice with olfactory bulb ablation. Jap. J. Pharmacol., 22, 447 (1972) https://doi.org/10.1254/jjp.22.447
  20. Swinyard, E.A., Brow, W.C. and Goodman, L.S.: Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol. Exptl. Therap., 106, 319 (1952)
  21. Vane, J.R.: A sensitive method for the assay for 5-hydroxytryptamine. Brit. J. Pharmacol., 12, 344 (1957)
  22. Mitruka, B.M. and Rawnsley, H.M.: Clinical biochem. and Hematol. Reference Values in normal exptl. animals and normal humans, 2nd ed, Masson Publ. USA, Inc., N.Y., 36 (1981)
  23. Guth, P.H., Aures, D. and Panlsen, G.: Topical aspirin plus HCI gastric lesions in the rat. Gastroenterol., 76, 88-89 (1979)
  24. 이은방: 생약의 약물학적 Approach. 약학회지, 19, pp. 53-59. Nahorski, S.R.: Behavioural supersensitivity to apomorphine following cerebral dopaminergic denevation by 6-hydroxydopamine. Psychopharmacologia. 42, 152-162 (1975)
  25. Sone, Y., Okuda, R.. Wada, N., Kshida, E. and Misaki, A.: Structures and antitumor activities of the polysaccharides isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum. Agri. BioI. Chem., 49, 2641-2653 (1985) https://doi.org/10.1271/bbb1961.49.2641
  26. Stavinoha, W.B., Hardman, W.E. and Cameron, I.L.: Short term dietary supplementation with Ganoderma lucidum slows development and growth of microadenomatous lesions in the colon of rats treated with the carcinogen 1,2-dimetylhydrazine. Prod. Int. Sym. on Ganoderma lucidum. June 17, 12-22, Seoul, Korea(1993)
  27. 식품의약품 안전 본부 내규 1997-2호, 일반약리시험 가이드라인(1997)