Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Two Cases of Acute Intoxication of Endosulfan

Endosulfan에 의한 급성 중독 2례

  • Lee Sang Jin (Department of Emergency Medicine,Colilege of Medicine, Ewha Womans University) ;
  • Jang Hye Young (Department of Emergency Medicine,Colilege of Medicine, Ewha Womans University) ;
  • Eo Eun Kyung (Department of Emergency Medicine,Colilege of Medicine, Ewha Womans University) ;
  • Jung Koo Young (Department of Emergency Medicine,Colilege of Medicine, Ewha Womans University)
  • 이상진 (이화여자대학교 의과대학 응급의학교실) ;
  • 장혜영 (이화여자대학교 의과대학 응급의학교실) ;
  • 어은경 (이화여자대학교 부속 목동병원 응급의학과) ;
  • 정구영 (이화여자대학교 의과대학 응급의학교실)
  • Published : 2003.12.01
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Abstract

Endosulfan, one of organochlorine insecticides, is $\gamma$-aminobutyric acid (GABA) antagonist. In sufficient dose, this pesticide lower the seizure threshold and produce CNS stimulation, with resultant seizures, respiratory failure, and death. In patients with endosulfan intoxication, the first manifestation of toxicity is largely a generalized seizure without prodromal signs or symptoms. So the management of airway and seizure control are essential for survival and prognosis of intoxicated patients. We report two cases of acute endosulfan poisoning who manifest 'status epilepticus' similarly, but have different prognosis.

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