Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Postmortem Blood and Tissue Concentration of Carisoprodol and Meprobamate

카리소프로돌 중독사의 치사혈중농도 및 조직분포

  • Choi Hye Young (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation) ;
  • Choi Hwa Kyung (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation) ;
  • Lee Ju Seon (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation) ;
  • Woo Sang Hee (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation) ;
  • Lee Han Sun (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation) ;
  • Park Yoo Sin (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation) ;
  • Chung Hee Sun (Div. of Drug & Toxicology, Dept. of Forensic Science National Institute of Scientific Investigation)
  • 최혜영 (국립과학수사연구소 법과학부 약독물과) ;
  • 최화경 (국립과학수사연구소 법과학부 약독물과) ;
  • 이주선 (국립과학수사연구소 법과학부 약독물과) ;
  • 우상희 (국립과학수사연구소 법과학부 약독물과) ;
  • 이한선 (국립과학수사연구소 법과학부 약독물과) ;
  • 박유신 (국립과학수사연구소 법과학부 약독물과) ;
  • 정희선 (국립과학수사연구소 법과학부 약독물과)
  • Published : 2003.12.01
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Abstract

Carisoprodol (CSP) is commonly prescribed as a skeletal muscle relaxant. Recently, we encountered 7 suicidal cases in which carisoprodol was detected. We developed a rugged, sensitive, and specific method for the determination of CSP and meprobamate (MPB) by GC and GC/MS. Postmortem blood concentrations of CSP and MPB ranged 22.9-124.4 ,$\mu$g/ml and its metabolite, 26.8-144.5 ,$\mu$g/ml respectively. Among 7 cases studied, Only CSP was ingested in 4 cases and combination of CSP and dextromethorphan was ingested in 2 cases according to the case history and one case was with ethanol. The order of the tissue concentration of CSP and MPB was liver> kidney > brain, and the concentration of MPB was higher than that of CSP in all tissues. The MPB /CSP concentration ratios of urine, bile juice, liver, kidney, brain and blood were 15.7, 4.0, 1.2, 1.4, 1.4 and 1.0 respectively. There was a big difference in concentration of CSP and MPB in 7 cases due to differences in the amount of dose administered and time to death after dosing.

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