대한한의학회지 (The Journal of Korean Medicine)

  • 제24권2호
  • /
  • Pages.204-212
  • /
  • 2003
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

백서의 국부 뇌경색에 대한 당귀의 신경보호 효과

The Neuroprotective Effects of Angelicae gigantis Radix on Focal Cerebral Ischemia in the Rat

  • 정정욱 (경산대학교 한의과대학 심계내과학교실) ;
  • 장우석 (경산대학교 한의과대학 심계내과학교실) ;
  • 오용성 (경산대학교 한의과대학 심계내과학교실) ;
  • 이소연 (경산대학교 한의과대학 심계내과학교실) ;
  • 박치상 (경산대학교 한의과대학 심계내과학교실) ;
  • 박창국 (경산대학교 한의과대학 심계내과학교실)
  • 발행 : 2003.06.01
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초록

Current therapy for acute ischemic stroke is highly focused on neuroprotective agents, and many herbal medicines have been challenged for experimental models. The aim of this study is to investigate whether Angelicae gigantis Radix can protect nerve cells against ischemic neural damage of middle cerebral artery occlusion (MCAO) in rats' brains. Rats were treated with Angelicae gigantis Radix immediately after 2 hours of MCAO for 7 days. On the 7th day, the brains of the rats were sliced through the hippocampus and dyedby c-Fos immunohistochemistry stain and cresyl violet stain for microscopic examination. The number of viable neurons and c-Fos immunoreactive cells in CA1 regions was counted. MCAO caused significant decrease in density of neurons and c-Fos immunoreactive cells compared to those of sham-operated rats. Administration of Angelicae gigantis Radix significantly elevated MCAO-induced decrease in density of neurons and c-Fos immunoreactive cells. These results suggest that the neuroprotective effect of Angelicae gigantis Radix against focal cerebral ischemia is related to c-Fos gene expression. Thus, these findings indicate that Angelicae gigantis Radix can be used for treatment and prevention of cerebral ischemia.

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