지부자 피부도포가 히스타민 유발 소양감, 홍반, 팽진에 미치는 영향

Effects of Kochiae Fructus on Histamine-induced Itch, Erythema and Wheal Responses in Normal Healthy Adults

  • 김정선 (경희대학교 대학원 동서의학과) ;
  • 한재복 (경희대학교 대학원 동서의학과) ;
  • 황의완 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 민병일 (경희대학교 대학원 동서의학과)
  • 발행 : 2003.03.01

초록

Objectives : Kochiae Fructus (dried fruits of Kochia scoparia L. Schrad,) is used in the treatment of skin diseases as internal or external medicine in Oriental Medicine, but there has not been experimental study of Kochiae Fructus as an external medicine. The purpose of this study was to investigate if it has certain effects on the skin or not. Methods : By a skin prick test method, we evaluated the effects of wet dressing with Kochiae Fructus decoction in different concentrations on histamine-induced itch, erythema and wheal responses, and compared them with the effects of calamine lotion and distilled water in 8 healthy volunteers aged 26-32. Results : The mean intensity and duration of itch were most decreased after wet dressing with a Kochiae Fructus decoction of 100mg/150ml. The time required for erythema to reach the maximal size was around 5 minutes in all groups, and the size of erythema was smallest on the skin taking wet dressing with the Kochiae Fructus decoction of highest concentration. The size of wheal was also smallest after wet dressing with the highest concentration Kochiae Fructus decoction. The effects of wet dressing with Kochiae Fructus decoction on skin were dependent on their concentrations. Conclusions : Kochiae Fructus suppressed the histamine-induced skin responses, which supports the ancient herbal literatures which describe that Kochiae Fructus has a certain effectiveness on some skin diseases.

키워드

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