Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Antigenicity Study on IDC7181, a Quaternary Ammoniopropenyl Cephalosporin Possessing Two Vinyl Groups

Cephalosporin계 항생제 IDC7181에 대한 항원성시험

  • 신지순 (충북대학교 수의과대학) ;
  • 장호송 (충북대학교 수의과대학) ;
  • 최은경 (충북대학교 수의과대학) ;
  • 권운 (충북대학교 수의과대학) ;
  • 채희열 (충북대학교 수의과대학) ;
  • 조영민 (충북대학교 수의과대학) ;
  • 김윤배 (충북대학교 수의과대학) ;
  • 강종구 (충북대학교 수의과대학)
  • Published : 2003.12.01
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Abstract

Antigenic potential of a novel cephalosporin, IDC7181 was examined a active systemic anaphylaxis (ASA) and passive cutaneous anaphylaxis (PCA) test, in guinea pig and mouse-rat models, respectively. In ASA test, IDC7181 induced the signs of restlessness in a few animals immunized with a high dose (100 mg/kg) of IDC7181 alone or in combination with Freund's complete adjuvant (FCA). In PCA test, only one of ten sera from the animals immunized with a high dose (100 mg/kg) of IDC7181 in the absence or presence of FCA showed positive reaction. The positive reaction, induced by IDC7181, which may be due to $\beta$-lactam ring, in ASA and PCA tests were negligible in comparison with those of traditional cephalosporins. Taken together, it is suggested that IDC7181 do not cause immunological problems in clinical dosage.

Keywords

References

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