Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)
- Volume 7 Issue 1
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- Pages.46-54
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- 2003
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- 1226-6531(pISSN)
Synthesis and Characterization of a Receptor-Targeting Contrast Agent
- Yang, Taegyun (Magnetic Resonance Team, Korea Basic Science Institute) ;
- Park, Ji-Hyung (Magnetic Resonance Team, Korea Basic Science Institute) ;
- Lee, Seung-Cheol (Magnetic Resonance Team, Korea Basic Science Institute) ;
- Kim, Cheol-Su (Magnetic Resonance Team, Korea Basic Science Institute) ;
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Cho, Jee-Hyun
(Magnetic Resonance Team, Korea Basic Science Institute) ;
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Lee, Chul-Hyun
(Magnetic Resonance Team, Korea Basic Science Institute) ;
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Cheong, Chae-Joon
(Magnetic Resonance Team, Korea Basic Science Institute)
- Published : 2003.06.01
Abstract
We synthesized a contrast agent for MRI that is capable of binding to the ABP-1 receptor and enhancing the contrast of the targeted cells. We used a lysine dendrimer (G=3)DTPA[Gd] as the contrast agent and synthesized a biotinylated polyclonal antibody for ABP-1 as the first antibody. Lysine dendrimers were prepared using the solid phase peptide synthesis method.
Keywords