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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Antiviral Activity of Novel trans-2,2-Dimethyl Cyclopropyl Nucleosides

  • Kook, Min-Chul (College of Pharmacy, Chonnam National University) ;
  • Choi, Bo-Gil (College of Pharmacy, Chonnam National University)
  • Published : 2003.11.01
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Abstract

Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 $\mu M$.

Keywords

References

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