YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

$\beta$-Lactamase Inhibitory Activity and Comparative Activity of 6-Exomethylenepenam Derivatives Combined with $\beta$-Lactam Antibiotics

6-Exomethylenepenam유도체의 베타락타마제 효소억제력과 베타락탐항생제 병용시 활성비교

  • 임채욱 (중앙대학교 약학대학 의약품화학 교실) ;
  • 박희석 (중앙대학교 약학대학 의약품화학 교실) ;
  • 정미량 (중앙대학교 약학대학 의약품화학 교실) ;
  • 강주성 (중앙대학교 약학대학 의약품화학 교실) ;
  • 임철부 (중앙대학교 약학대학 의약품화학 교실)
  • Published : 2003.12.01
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Abstract

In vitro $\beta$-lactamase inhibitory activity of 6-exomethylenepenam compounds ( 1, 2, 3, 4 and 5) was compared with clavulanic acid, sulbactam and tazobactam. The inhibitory activity of compound 3 was stronger than those of sulbactam and clavulanic acid against Type I and II enzymes and stronger than tazobactam against Type III, IV, TEM enzymes. The inhibitory activity of 5 was stronger than sulbactam and clavulanic acid against Type I and II enzymes and stronger than tazobactam against Type III, and IV enzymes. The in vitro antimicrobial activity of 3, 4 and 5 combined with ampicillin and cefoperazone was compared with the sulbactam against $\beta$-lactamase producing 27 strains. But, synergistic activity of 3 and 5 was inferior to tazobactam.

Keywords

References

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