YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

2-Arylethenylchromone Derivatives : Synthesis and Anticancer Activity

2-Arylethenylchronlones유도체의 합성 및 항암활성 검색

  • 문창상 (한국과학기술연구원 생체과학연구부 의약화학센터) ;
  • 이경원 (경희대학교 약학대학) ;
  • 이지용 (한국과학기술연구원 생체과학연구부 의약화학센터) ;
  • 이재열 (한국과학기술연구원 생체과학연구부 의약화학센터) ;
  • 정봉영 (고려대학교 화학과) ;
  • 이경태 (경희대학교 약학대학) ;
  • 이용섭 (한국과학기술연구원 생체과학연구부 의약화학센터)
  • Published : 2003.12.01
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Abstract

2-Arylchromones, also known as flavones, are among the most ubiquitous classes of natural products occurring in the plant kingdom. On the other hand, 2-styrylchromones are relatively scarce in nature and only a few compounds has been isolated from the blue-green algae species. Therefore, new 2-arylethenylchromone derivatives ( 4a∼n, 5a∼f) were synthesized by the aldol condensation of 2-methylchromone ( 3) with several aromatic aldehydes in order to evaluate their cytotoxicities using a MTT assay on three tumor cells. 2-Arylethenylchromone derivative 4a showed the significant cytotoxic activities on KB, HL-60 and P-388 cell lines with $IC_{50}$/ values of 25.2, 63.59 and 49.51 $\mu$M, respectively, indicating that 2-arylethenylchromone skeleton has a potential anti-tumor application.

Keywords

References

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