YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Potentiometric Characteristics of Nitroso.R-Salt-Metal Complex Based Basic Drug Selective Electrodes

금속 니트로소 R염 착물을 이용한 염기성 의약품 선택성 전극의 특성

  • Published : 2003.12.01
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Abstract

Nitroso-2-naphthol-3,6-disulfonic acid, disodium salt (NRS) was used as an organic ligand to prepare basic drug-selective polymeric membrane electrode. The sensing membrane of the electrode consited of basic drug-meta1(II)-NRS as an ion-exchanger site in a poly(vinyl chloride) matrix plasticized with 2-nitrophenyl octyl ether (NPOE). The metal ions used were Fe$^{2+}$, Co$^{2+}$, Ni$^{2+}$ and Cu$^{2+}$. The electrodes exhibited fast and wide linear response in the basic drug concentration of 10$^{-5}$ ∼10$^{-3}$ mol/l with a response slope of 50∼60 mV/decade in a buffer solution of pH 4∼8. The electrodes exhibited good selectivity for many basic compounds.mpounds.

Keywords

References

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