대한후두음성언어의학회지 (Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics)
- 제14권1호
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- Pages.54-56
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- 2003
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- 2508-268X(pISSN)
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- 2508-5603(eISSN)
Valproic Acid 복용에 의해 유발된 연축성 발성장애 1예
Spasmodic Dysphonia Induced by Valproic Acid
초록
Spasmodic dysphonia is a task-specific dystonia affecting the laryngeal muscles, resulting forced, strained voice. The pathophysiologic mechanism is not fully understood. We experienced a patient with epilepsy developed transient spasmodic dysphonia during valproic acid monotherapy. The spasmodic dysphonia resolved with dose reduction of valproic acid. Change of neurotransmitters, such as GABA in basal ganglia or blockade of sodium channel is possible mechanism in our case of drug-related spasmodic dysphonia.