Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Pheophorbide A-methyl Ester, Acyl-CoA: Cholesterol Acyltransferase Inhibitor from Diospyros kaki

  • Rho, Mun-Chual (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Chung, Mi-Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Song, Hye-Young (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kwon, Oh-Eok (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Seung-Woong (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Baek, Jin-Ah (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Jeune, Kyung-Hee (Department of Biology, Yeungnam University) ;
  • Kim, Koan-Hoi (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Kook (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2003.09.01
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Abstract

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an $IC_{50}$ value of 1.85 $\mu$ g/mL.

Keywords

References

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