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The Pharmaceutical Society of Korea (대한약학회)
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Modulation of $TNF-{\alpha}-induced$ ICAM-1 Expression, NO and $H_2O_2$ Production by Alginate, Allicin and Ascorbic Acid in Human Endothelial Cells

  • Mo, Sung-Ji (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Son, Eun-Wha (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Rhee, Dong-Kwon (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Pyo, Suhkneung (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2003.03.01
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Abstract

Plant nutrients are believed to provide protection against various diseases including inflammation. Since interactions of the cell adhesion molecules are known to play important roles in mediating inflammation, inhibiting adhesion protein upregulation is a possible therapeutic target. In this study, the interacellular adhesion molecule-1 (ICAM-1) was induced in human umbilical endothelial cells (HUVECs) after stimulation with $TNF-{\alpha}$. In addition, alginate, ascorbic acid and allicin were demonstrated to inhibit the $TNF-{\alpha}$ induced expression of ICAM-1 on the HUVECs in a dose-dependent manner. These compounds also inhibited the production of NO and $H_2O_2$ induced by $TNF-{\alpha}$, which suggests that the inhibition of ICAM-1 expression by the three compounds may be due to the modulated production of the reactive oxygen/nitrogen components. Overall, these results indicate that these dietary components have a therapeutic potential in the treatment of various inflammatory disorders associated with an increase in endothelial leukocyte adhesion molecules.

Keywords

References

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