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The Pharmaceutical Society of Korea (대한약학회)
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In Vivo Anti-Oxidant Activities of Tectochrysin

  • Lee, Sang-Hyun (College of Pharmacy, Seoul National University, Natural Products Research Institute, Seoul National University) ;
  • Kim, Kyoung-Soon (College of Pharmacy, Seoul National University) ;
  • Park, You-Mie (College of Pharmacy, Seoul National University) ;
  • Shin, Kuk-Hyun (Seokwon Life Science Research Institute) ;
  • Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
  • Published : 2003.01.01
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Abstract

The anti-oxidant activities of tectochrysin, a major compound of propolis, were investigated. Tectochrysin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats. Tectochrysin tested exhibited a lipid peroxidation causing a significant decrease in MDA production in TBA-reactant assay. Tectochrysin was strong in the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase activities in $CCl_4$-intoxicated rats. These results suggest that tectochrysin possess not only the anti-oxidant, but also the activities in $CCl_4$-intoxicated rats. Especially, tectochrysin was found to cause significant increases in the rat liver cytosolic SOD, catalase, GSH-px activities as well as a significant decrease in the MDA production.

Keywords

References

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