YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Analysis of 3,4-Methylendedioxymethamphetamine (MDMA) in Human Hair by Gas Chromatography/Mass Spectrometry

GC/MS를 이용한 모발 중 MDMA(Methylendedioxymethamphetamine)의 분석

  • 박미정 (국립과학수사연구소 법과학부) ;
  • 김은미 (국립과학수사연구소 법과학부) ;
  • 임미애 (국립과학수사연구소 법과학부) ;
  • 정희선 (국립과학수사연구소 법과학부)
  • Published : 2003.08.01
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Abstract

An analysis method for the determination of methylendedioxymethamphetamine (MDMA) and its metabolite methylendedioxymethamphetamine (MDA) in hair by gas chromatography/mass spectrometry was proposed. For MDMA and MDA analysis, hair samples were incubated in MeOH (1％ HCl), derivatized with trifluoroacetic anhydride and assayed by GC/MS. Hair of 18 subjects for drug abuse was analyzed for MDMA and MDA. Calibration curves for the determination of MDMA and MDA in hair showed a good linearity at a concentration range from 0.5 ng to 250 ng ($r^2$=0.999) The extraction recovery was determined from hair blanks at 50, 100 ng. The percentage of recovery were found to be 96.08∼103.48 with CV value of 1.62∼3.89. The concentrations of MDMA and MDA ranged 1.14∼38.06 ng/mg and 0.07∼3.91 ng/mg, respectively in 18 hair samples from MDMA abusers. The ratio of MDMA to MDA ranged from 9.65∼28.46 in all specimen. Hair analysis for MDMA is a useful method for identification of long-term drug abuser.

Keywords

References

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