YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Identification of TRAF6-Binding Motif in IL-1/Toll-like Receptor Superfamily-Mediated Signal Transduction

IL-l/Toll-like Receptor Superfamily 신호전달에 관여하는 TRAF6 결합 Motif의 규명

  • Published : 2003.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Crystal structure of TRAF6 in complex with TRAF6-binding sites from CD40 was previously determined. The structure revealed a distinct TRAF6-binding groove of CD40, the key structural determinant of interaction. The structural information leads to a proposed TRAF6-binding motif. This allows the identification of TRAF6-binding sequences in the hIRAK protein, whose functional requirement in IL-1/Toll-like receptor superfamilies-mediated signal transduction is further demonstrated using site-directed mutagenesis. The mutational effects of hIRAK on the down-stream NF-kB signaling shows the importance of the TRAF6 interface for signaling by IL-1/Toll-like receptor superfamilies.

Keywords

References

  1. Clin. Orthop. v.393 Osteolysis : basic science Jacobs, J. J.;Roebuck, K. A.;Archibeck, M.;Hallab, N. J.;Glant, T. T. https://doi.org/10.1097/00003086-200112000-00008
  2. Q. J. Nucl. Med. v.45 Physiopathological basis of bone turnover Masi, L.;Brandi, M. L.
  3. Rev. Endocr. Metab. Disord. v.2 Regulation of osteoclast formation and function Duong, L. T.;Rodan, G. A. https://doi.org/10.1023/A:1010063225902
  4. Blood v.98 Bifurcation of osteoclasts and dendritic cells from common progenitors Miyamoto, T.;Ohneda, O.;Arai, F.;Iwamoto, K.;Okada, S.;Takagi, K.;Anderson, D. M.;Suda, T. https://doi.org/10.1182/blood.V98.8.2544
  5. Lupus. v.11 Osteoporosis in the rheumatic disease patient Lane, N. E.;Rehman, Q. https://doi.org/10.1191/0961203302lu261oa
  6. Croat. Med. J. v.42 Cellular and molecular interactions between immune system and bone Grcevic, D.;Katavic, V.;Lukic, I. K.;Kovacic, N.;Lorenzo, J. A.;Marusic, A.
  7. Nature v.383 TRAF6 is a signal transducer for interleukin-1 Cao, Z.;Xiong, J.;Takeuchi, M.;Kurama, T.;Goeddel, D. V. https://doi.org/10.1038/383443a0
  8. Biochemistry v.38 High-affinity interactions of tumor necrosis factor receptor-associated factors TRAFs) and CD40 require TRAF trimerization and CD40 multimerization Pullen, S. S.;Labadia, M. E.;Ingraham, R. H.;McWhirter, S. M.;Everdeen, D. S.;Alber, T.;Crute, J. J.;Kehry, M. R. https://doi.org/10.1021/bi9909905
  9. Nature v.418 Distinct molecular mechanism for initiating TRAF6 signalling Ye, H.;Arron, J. R.;Lamothe, B.;Cirilli, M.;Kobayashi, T.;Shevde, N. K.;Segal, D.;Dzivenu, O. K.;Vologodskaia, M.;Yim, M.;Du, K.;Singh, S.;Pike, J. W.;Darnay, B. G.;Choi, Y.;Wu, H. https://doi.org/10.1038/nature00888
  10. J. Biol. Chem. v.273 The TRAF family of signal transducers mediates NF-kB activation by the TRANCE receptor Wong, B. R.;Josien, R.;Lee, S. Y.;Vologodskaia, M.;Steinman, R. M.;Choi, Y. https://doi.org/10.1074/jbc.273.43.28355
  11. EMBO J. v.20 Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis Kobayashi, N.;Kadono, Y.;Naito, A.;Matsumoto, K.;Yamamoto, T.;Tanaka, S.;Inoue, J. https://doi.org/10.1093/emboj/20.6.1271
  12. Proc. Natl. Acad. Sci. U.S.A. v.98 IL-1-induced NF-kB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK) Li, X.;Commane, M.;Jiang, Z.;Stark, G. R. https://doi.org/10.1073/pnas.071054198
  13. J. Biol. Chem. v.277 A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6 Shin, J. N.;Kim, I.;Lee, J. S.;Koh, G. Y.;Lee, Z. H.;Kim, H. H. https://doi.org/10.1074/jbc.M110964200
  14. Clin. Geriatr. Med. v.18 Osteoporosis in elderly: prevention and treatment Srivastava, M.;Deal, C. https://doi.org/10.1016/S0749-0690(02)00022-8
  15. Cancer. v.97 A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases Body, J. J.;Greipp, P.;Coleman, R. E.;Facon, T.;Geurs, F.;Fermand, J. P.;Harousseau, J. L.;Lipton, A.;Mariette, X.;Williams, C. D.;Nakanishi, A.;Holloway, D.;Martin, S. W.;Dunstan, C. R.;Bekker, P. J. https://doi.org/10.1002/cncr.11138