약학회지 (YAKHAK HOEJI)

  • 제47권2호
  • /
  • Pages.85-92
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  • 2003
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

뇌신경세포에서 토양미생물 발효추출액인 석정의 카드뮴 독성에 대한 방어효과

Protective Effects of Seok-Jeong on the Toxicity of Cadmium in Neuronal Cells

  • 홍순해 (순천향대학교 환경보건학과) ;
  • 안성희 (순천향대학교 환경보건학과) ;
  • 장봉기 (순천향대학교 환경보건학과) ;
  • 박종안 (순천향대학교 환경보건학과) ;
  • 이종화 (순천향대학교 환경보건학과)
  • 발행 : 2003.04.01
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초록

Seok-jeong (SJ) is a solution of various metal ions and numerous other organic substances produced through extraction and fermentation of herbs and soil using geo-microbes, and it has been shown to improve symptoms of senile dementia. In this study, we investigated the protective effects of SJ against neurotoxicity of cadmium in HT22 hippocampal neuron cell line. SJ significantly protected from the cadmium-induced decreased cell viability measured by MTT assay (p＜0.01). The protective effects of SJ against cadmium toxicity were confirmed through observing morphological changes using inverted microscope. Additionally, SJ significantly repressed the formation of lipid peroxidation induced by high concentration of cadmium, and likewise, significantly repressed the reduction of glutathione by cadmium in HT22 cells. Vitamin C at the concentration found in SJ did not show any protective effect against cadmium toxicity in HT22 cells, indicating that vitamin C may not have a major role in the protective mechanism of SJ. Taken together, these results suggest that SJ may be a valuable agent for the protection of cadmium toxicity on the neuronal cells, and that the mechanism of the action of SJ may be due to reduced lipid peroxidation and increased glutathione level.

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