한국작물학회지 (KOREAN JOURNAL OF CROP SCIENCE)

  • 제48권
  • /
  • Pages.31-40
  • /
  • 2003
  • /
  • 0252-9777(pISSN)
  • /
  • 2287-8432(eISSN)
한국작물학회 (The Korean Society of Crop Science)
권호 표지

작물에 함유된 Phytoestrogen의 특성과 생리활성

Biological Activities of Phytoestrogens in Plant and Foodstuff

  • 김성란 (한국식품개발연구원 식품기능연구본부) ;
  • 최선영 (한국식품개발연구원 식품기능연구본부) ;
  • 안지윤 (한국식품개발연구원 식품기능연구본부) ;
  • 하태열 (한국식품개발연구원 식품기능연구본부)
  • 발행 : 2003.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Phytoestrogens are oestrogenic compounds found in plants and consist of isoflavones, lignans, and coumestans. The structural similarity of phytoestrogens to endogenous oestrogens has promoted the hypothesis that phytoestrogens exert hormonal or anti-hormonal effects relevant to the risk of hormone-dependent disease and/or their suitability as a dietary alternative to hormone replacement therapy. Epidemiological studies suggest that food stuffs containing phytoestrogens may have a beneficial role in protecting against a number of chronic disease and conditions. It is thought that these estrogen-like compounds may protect against chronic diseases, such as hormone-dependent cancers, cardiovascular disease and osteoporosis. Furthermore, phytoestrogens are used as a natural alternative to hormone replacement therapy and to reduce menopausal symptoms. Phytoestrogens are considered good candidates for use in natural therapies and as chemopreventive agents in adults. However safe and efficacious levels have yet to be established.

키워드

참고문헌

  1. Adlercreutz H. 2002. Phyto-oestrogens and cancer. Lancet Oncology 3 : 364-373 https://doi.org/10.1016/S1470-2045(02)00777-5
  2. Adlercreutz H., Bannwart C., Wahala K. et al. 1993. Inhibition of human aromatase by mammalian lignans and isoflavonoid phy-toestrogens. Journal of Steroid Biochemistry and Molecular Biol-ogy 44: 147-153 https://doi.org/10.1016/0960-0760(93)90022-O
  3. Adlercreutz H., Fotsis T., Bannwart C. et al. 1986. Determination of urinary lignans and phytoestrogen metabolites, Potential anti-oestrogens and anticarcinogens, in urine of women on various habitual diets. Journal of Steroid Biochemistry 25 : 791-797 https://doi.org/10.1016/0022-4731(86)90310-9
  4. Adlercreutz H., van der Wildt J., Kinzel J. et al. 1995. Lignan and isoflavonoid conjugates in human urine. J. Steroid Biochem. Mol. Biol. 52 : 97-103 https://doi.org/10.1016/0960-0760(94)00146-D
  5. Allen E. and Doisy E.A. 1923. An ovarian hormone. Preliminary report on its localization, extraction and purification, and action in test animals. JAMA 81 : 819-821 https://doi.org/10.1001/jama.1923.02650100027012
  6. Anderson J.W., Johnstone B.M., and Cook-Newell M.E. 1995. Meta-analysis of the effects of soy protein intake on serum lipids. New England J. Medicine 333 : 276-282 https://doi.org/10.1056/NEJM199508033330502
  7. Anthony M.S., Clarkson T.B., and Williams J.K. 1998 8. Effects of soy isoflavones on atherosclerosis: potential mechanisms. Am. J. Clin. Nutr. 68 : 1390S-1393S
  8. Bradbury R.B. and White D.E. 1954. Estrogens and related substances in plants. In : Haaris R.S., Marrian G.E., Thiamin K.V., eds. Vita-mins and hormones. Advances in research and applications. New York. Academic Press Inc., 207
  9. Brenneatts H.W., Underwood, E.J., Shier, F.L. 1946. A specific breed-ing problem of sheep on subterranean clover pastures in Western Australia. Aust Vet J. 22 : 2-12 https://doi.org/10.1111/j.1751-0813.1946.tb15473.x
  10. Bridgette, M., C-B, Metthew E.B., Bich N.D. and John, A.M. 2000. Estrogenic and antiestrogenic activities of flavonoid phytochemi-cals through estrogen receptor binding-dependent and independent mechanisms. Nutr. and Cancer 38 : 229-244 https://doi.org/10.1207/S15327914NC382_13
  11. Brzezinski A., Adlercreutz H., Shaoul R. et al. 1997. Short-term Effects of phytoestrogen-rich diet on post-menopausal women. Menopause. 4: 89-94
  12. Busby M.G., Jeffcoat A.R., Bloedon L.T. et al. 2002. Clinical charac-teristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am. J. Clin. Nutr. 75 : 126-136
  13. Cassidy, A. and Griffin, B., 1999. Phyto-oestrogens; a potential role in the prevention of CHD. Proc. Nutr. Soc. 58 : 193-199 https://doi.org/10.1079/PNS19990025
  14. Cassidy, A. Potential tissue selectivity of dietary phytoestrogens and estrogens. Current Opio. Lipidol. 10 : 47
  15. Clarkson T.B. 2002. Soy, soy phytoestrogens and cardiovascular disease.J. Nutr. 132 : 566S-569S
  16. Clemons M. and Goss P. 2001. Oestrogen and the risk of breast cancer. New England Journal of Medicine. 344 : 276-285 https://doi.org/10.1056/NEJM200101253440407
  17. Dai Q., Shu X. O., Jin F. et al. 2001. Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. British Journal of Cancer. 85 : 372-378 https://doi.org/10.1054/bjoc.2001.1873
  18. Dai Q., Shu X. O., Jin F. et al. 2001. Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. British Journal of Cancer. 85 : 372-378 https://doi.org/10.1054/bjoc.2001.1873
  19. de Kleijin M.J., van der Schouw Y.T., Wilson P.W. et al. 2002. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in post-menopausal U.S. women: the Framingham study. J. Nutr. 132 : 276-282
  20. de Kleijn M.J., van der Schouw Y.T., Wilson P.W. et al. 2001. Intake of dietary phytoestrogens is low in post-menopausal women in the United States: the Framingham study. J. Nutr. 131 : 1826-1832
  21. Demark-Wahnefried W., Price D.T., Polascik T.J. et al. 2001. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, Prostate-specific antigen, and histopathologic fea-tures. Urology. 58 : 47-52 https://doi.org/10.1016/S0090-4295(01)01014-7
  22. Duncan, A.M., Phipps, W.R., and Kurzer, M.S. 2003. Phyto-oestro-gens. Best Practice Res. Clin. Endo. Met. 17 : 253-271 https://doi.org/10.1016/S1521-690X(02)00103-3
  23. Evans B.A., Griffiths K. and Morton M.S. 1995. Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. JournaI of Endocrinology. 147 : 295-302 https://doi.org/10.1677/joe.0.1470295
  24. Farnsworth N.R., Bingel A.S., Cordell G.A., Crane F.A., and Fong H.H.S. 1975. Potential value of plant as sources of new antifertility agents II. J. Pharm Sci. 64 : 717 https://doi.org/10.1002/jps.2600640504
  25. Hargreaves D.E, Potten C.S., Harding C. et al. 1999. Two-week dietary soy supplementation has an oestrogenic effect on normal premenopausal breast. J. Clin. Endocrinol. Metab. 84 : 4017-4024 https://doi.org/10.1210/jc.84.11.4017
  26. Humfrey, C. 1998. Phytoestrogenes and human health effects : Weigh-ing up the current evidence. Nat. Toxins 6 : 51-59 https://doi.org/10.1002/(SICI)1522-7189(199804)6:2<51::AID-NT11>3.0.CO;2-9
  27. Jung, W., Yu, O., Sze-Mei, C.L., O'Keefe, D.R, Odell, J., Fader, G. and McGonigle, B. 2000. Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavone in legumes. Nat. biotechnol. 18 : 208-213 https://doi.org/10.1038/72671
  28. King R.A., and Bursill D.B. 1998. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am. J. Clin. Nutr. 67 : 867-872
  29. King, R.A. 2002. Digestion, absorption and metabolism of isofla-vones. In : Gilani, G.S. and Anderson, J. J. B. eds. Phytoestrogens and Health. AOCS press. 220
  30. Krazeisen A., Breitling, Moller G., and Adamski J. 2001. Phytoestro-gens inhibit human 17 beta-hydroxysteroid dehydrogenase type 5. Molecular and Cellular Endocrinoloey. 171 : 151-162 https://doi.org/10.1016/S0303-7207(00)00422-6
  31. Kuiper, G.G., Lemmen, J.G., Carlsson, B., Corton, J.C., Safe, S.H., van der Saag, P. T. van der Burg, B., and Gustafsson, J. A. 1998. Interaction of estrogenic chemicals and phytoestrogens with estro-gen receptor beta. EndocinoIogy 139 : 4252-4263 https://doi.org/10.1210/en.139.10.4252
  32. Lamartinie, C.A., Murrill, W.B., Manzolillo, P.A., Zhang, J.X., Bar-nes, S., Zhang, X., Wei, H., and Brown, N.M. 1998. Genistein alters the ontogeny of mammary gland development and protects against chemistry-induced mammary cancer in rats. Proc. Soc. Exp. Biol. Med. 217 : 358-364
  33. Lampe, J.W., Karr, S.C, Huychins, A.M., and Slavin, J.L. 1998. Urinary equol excretion with a soy challenge : influence of habitual diet. Exp. Biol. Med. 217 : 335-339 https://doi.org/10.3181/00379727-217-44241
  34. Lucas E.A., Wild R.D., Hammond L.J. et al. 2002. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in post-menopausal women. J. CIin. Endocrinol. Metab. 87 : 1527-1532 https://doi.org/10.1210/jc.87.4.1527
  35. Mazur W., and Adlercreutz H. 2000. Overview of naturally occuring endocrine-active substances in the human diet in relation to human health. Nutrition. 16 : 654-687 https://doi.org/10.1016/S0899-9007(00)00333-6
  36. Mazur, W.M. 1998. Phytoestogen content in foods, Bailliere's Clin. Endoclinol. Metab. 12 : 729-741 https://doi.org/10.1016/S0950-351X(98)80013-X
  37. Mazur, W.M., Duke, J.A. and W$\ddot a h \ddot a l \ddot a$, K. 1998. Isoflavonoids and lignana in legumes: Nutritional and health aspects in the human, J. Nutr. Biochem. 9: 193-200 https://doi.org/10.1016/S0955-2863(97)00184-8
  38. McCann S.E., Moysich K.B., Freudenheim J. L. et al. 2002. The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. J. Nutr. 132 : 3036-3041
  39. Messina M. and Messina V. 2000. Soyfoods, soybean isoflavones, and bone health: a brief overview. Journal of Renal Nutrition. 10 : 63-68 https://doi.org/10.1016/S1051-2276(00)90001-3
  40. Messina M.J. and Loprinzi C.L. 2001. Soy for breast cancer survivors: a critical review of the literature. J. Nutr. 131 : 3095S-3108S
  41. Miksicek R.J. 1995. Estrogenic flavonoids: structural requirements for biological activity. Proc. Soc. Exp. Biol. Med. 208 : 44
  42. Morton M.S., Chan P.S., Cheng C. et al. 1997. Lignans and isofla-vonoids in plasma and prostatic fluid in men: samples from Portu-gal, Hong Kong, and the United Kingdom. Prostate. 32 : 122-128 https://doi.org/10.1002/(SICI)1097-0045(19970701)32:2<122::AID-PROS7>3.0.CO;2-O
  43. Murkies A.L., Wilcox G. and Davis S.R. 1998. Clinical Review 92: phytoestrogens. J. Clin. Endocrinol. Metab
  44. Onozawa M., Fukuda K., Ohtani M. et al. 1998. Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. Japanese Journal of Endocrinology. 28 : 360-363
  45. Petrakis N.L., Barnes S., King E.B. et al. 1996. Stimulatory influence of soy protein isolate on breast secretion in pre- and post-meno-pausal women. Cancer Epidemiol. Biomarkers Prev. 5 : 785-794
  46. Setchell K.D. 1998. Phytoestrogens: the biochemistry, Physiology, and implications for human health of soy isoflavones. Am. J. Clin. Nutr.68: 1333S-1346S
  47. Setchell K.D. 2000. Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants. J. Nutr. 130 : 654S-655S
  48. Setchell K.D. and Cassidy A. 1999. Dietary isoflavones: biological effects and relevance to human health. J. Nutr. 129 : 758S-767S
  49. Setchell K.D. R. and Adlercreutz H. 1988. Mammalian lignans and phyto-estrogens. Recent studies on their formation, metabolism and biological role in health and disease. In Rowland IR (ed) Role of the Gut Flora in Toxicity and Cancer. London: Academic Press
  50. Setchell K.D,, Brown N.M., Desai P. et al. 2001. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J. Nutr. 131 : 1362S-1375S
  51. Setchell K.D., Brown N. M., Zimmer-Nechemias L. et al. 2002. Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am. J. Clin. Nutr. 76 : 447-453
  52. Setchell K.D., Zimmer-Nechemias L., Cai J. and Heubi J. E. 1998. Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life. Am. J. Clin. Nutr. 68 : 1453S-1461S
  53. Stephens F.O. 1997. Phytoestrogens and prostate cancer: possible pre-ventive role. Medicinal Journal of Australia. 167 : 138-140
  54. Strom B.L., Schinnar R., Ziegler E.E. et al. 2001. Exposure to soybased formula in infancy and endocrinological and reproductive outcomes in young adulthood. J. Am. Medical Association. 286 : 807-814 https://doi.org/10.1001/jama.286.7.807
  55. Thompson L. U., Richard S.E., Cheung F. et al. 1997. Variability in anticancer lignan levels in flaxseed. Nutrition and Cancer. 27 : 26- 30 https://doi.org/10.1080/01635589709514497
  56. Thompson L.U., Robb P, Serraino M. and Cheung F. 1991. Mamma-lian lignan production from various foods. Nutrition and Cancer. 16 :43-52 https://doi.org/10.1080/01635589109514139
  57. Urban D., Irwin W., Kirk M. et al. 2001. The effect of isolated soypro-tein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. JournaI of Urology. 165 : 294-300 https://doi.org/10.1097/00005392-200101000-00082
  58. van der Schouw Y.T., Pijpe A., Lebrun C.E. et al. 2002. Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in post-menopausal women. Arterioscler. Thromb. Vasc. Biol.22: 1316-1322 https://doi.org/10.1161/01.ATV.0000027176.83618.1A
  59. Vanharanta M., Voutilainen S., Lakka T.A. et al. 1999. Risk of acute coronary events according to serum concentrarions of enterolactone: a prospective population-based case-control study. Lancet. 354: 2112-2115 https://doi.org/10.1016/S0140-6736(99)05031-X
  60. Vanharanta M., Voutilainen S., Nurmi T. et al. 2002. Association between low serum enterolactone and increased plasma F2-iso-prostanes, a measure of lipid peroxidaion. Artherosclerosis. 160 :465-469 https://doi.org/10.1016/S0021-9150(01)00603-7
  61. Wang H.J. and Murphy P.A. 1994(a). Isoflavone content in commer-cial soybean foods. J. Agric. Food Chem. 42 : 1666-1673 https://doi.org/10.1021/jf00044a016
  62. Wang H.J. and Murphy P. A. 1994(b). Isoflavone composition of American and Japanese soybeans in lowa : effects of variety, crop year, and location. J. Agric. Food Chem. 42 : 1674-1677 https://doi.org/10.1021/jf00044a017
  63. Wangen K.E., Duncan A.M., Merz-Demlow B.E. et al. 2000. Effects of soy isoflavones on markers of bone turnover in premenopausal and post-menopausal women. J. Clin. Endocrinol. Metab. 85 : 3043-3048 https://doi.org/10.1210/jc.85.9.3043
  64. Watanabe, S., Yamaguchi, M., Sobue, T., Takahashi, T, Miura., T, Arai, Y., Mazur, W., and Adlercreutz H. (1998) Pharmakokinetics of soybean isoflavones in plasma, urine, and feces of men after ingestion of 60g baked soybean powder(Kinako). J. Nutr. 128 : 1710-1715
  65. Winkel-Shireley, B. 2001. Flavonoid biosynthesis. a colorful model for genetics, biochemistry, cell biology and biotechnology. Plant Physiol. 126 : 485-493 https://doi.org/10.1104/pp.126.2.485
  66. Wood, C., Barens S. and Cline J.M. 2002. Phytoestrogen actions in the breast and uterus In : Gilani, G.S. and Anderson, J. J. B. eds. Phy-toestrogens and Health. AOCS press. 371