대한지역사회영양학회지 (Korean Journal of Community Nutrition)

대한지역사회영양학회 (The Korean Society of Community Nutrition)
권호 표지

한국 여자 노인의 Carotenoid Bioavailability에 미치는 요인 조사

Factors Effecting the Bioavailability of Carotenoid in Elderly Korean Women

  • 임재연 (서울대학교 생활과학대학 식품영양학과) ;
  • 이해정 (서울대학교 생활과학대학 식품영양학과) ;
  • 박선주 (서울대학교 생활과학대학 식품영양학과) ;
  • 최혜미 (서울대학교 생활과학대학 식품영양학과)
  • 발행 : 2003.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Carotenoid-rich foods focus one's attention on the prevention age-related diseases. This study was conducted to investigate the carotenoid status and look into the factors that affect the bioavailability of carotenoid in 121 elderly nonsmoking Korean women. Carotenoids and lipids in plasma, and nutrient intakes including carotenoid were studied. The mean plasma total-cholesterol, HDL-cholesterol, LDL-cholesterol and triacylglycerol concentrations were 220.0 mg/dl 49.5mg/dl , 139.2mg/dl and 157.4mg/dl , respectively. Significantly positive correlations were found between the plasma lutein + zeaxanthin, lycopene and $\beta$-carotene concentrations and the intake of fruits (r=0.17, r=0.20, r=0.19). However, significantly negative correlations were found between the plasma zeaxanthin, and $\beta$-carotene concentrations that adjusted for carotenoid intakes and intakes of vegetables (r=-0.21, r=-0.19), and between plasma lutein＋zeaxanthin, lycopene and $\beta$-carotene concentrations that adjusted for carotenoid intakes and intakes of fruits (r= -0.21, r=-0.18, r=-0.24). After the adjustment for plasma lipids, there was no correlation between the plasma carotenoid concentrations and the carotenoid-rich foods. However, after adjustment for fiber intake, significantly strong positive correlations were found between the plasma carotenoid concentrations and carotenoid-rich foods. The plasma levels of carotenoid biomarkers (plasma carotenoid concentrations adjusted for dietary fiber intakes) decreased with age, and the plasma levels of lycopene biomarkers (plasma lycopene concentrations adjusted for dietary fiber intakes) increased with regular exercise. However alcohol drinking had no impact. These results suggested that age, physical activity, and dietary fiber intake affected the bioavailability of carotenoid. Therefore, when the elderly have carotenoid-rich foods, they should consider ways of increasing the bioavailability of carotenoid through cooking methods and Physical activity.

키워드

참고문헌

  1. Adam D, Cheryl LR, Susan AH, Amy BS, Claude F, Pilar G, Paul P, Serge H (1997): Serum beta-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults. Am J Clin Nutr 65: 1792-1802
  2. Bieri JG, Brown ED, Smith JC (1985): Determination of individual carotenoids. Chrom 8: 473-487
  3. Borel P, Tyssandier V, Mekki N, Grolier P, Rochhhette Y, Alexandre-Gouabau MC, Lairon D, Azais-Braesco V (1998): Chylonmicron beta-carotene and retinyl palmitate responses are dramatically diminished when men ingest beta-carotene with medium-chain rather than long-chain triglycerides. J Nutr 128: 1361-1367
  4. Brady WE, Mares-Perlman JA, Bowen P, Stacewicz-Sapuntzakis M (1996): Human serum carotenoid concentrations are related to physiologic and lifestyle factors.J Nutr 126: 129-137
  5. Bub A, Watzl B, Abrahamse L, Delincee H, Adam S, Wever J, Muller H, Rechkemmer G (2000): Moderate intervention with carotenoidrich vegetable products reduces lipid peroxidation in men. J Nutr 130: 2200-2206
  6. Castenmiller JJM, Lauridsen ST, Dragsted LO, Vanhet Hof KH, Linssen JPH, West CE (1999): $\beta$-carotene does not change markers of enzymatic and nonenzymatic antioxidant activity in human blood. J Nutr 129: 2162-2169
  7. Clinton SK (1998): Lycopene: chemistry, biology, and implications for human and disease. Nutr Rev 56: 35-51 https://doi.org/10.1111/j.1753-4887.1998.tb01691.x
  8. DiMascio P, Kaiser S, Sies H (1989): Lycopene as the most efficient biological carotenoids singlet oxygen quencer. Arch Biochem Biophys 274: 532-538 https://doi.org/10.1016/0003-9861(89)90467-0
  9. DiMascio P, Murphy ME, Sies H (1991): Antioxidant defense system: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 53: 194s-200s
  10. Dugas TR, Morel DW, Harrison EH (1999): Dietary supplementation with $\beta$carotene, but not with Iycopene inhibits endothelial cellmediated oxidation of low density lipoprotein. Free Radical Biol & Med 26: 1238-1244 https://doi.org/10.1016/S0891-5849(98)00321-9
  11. Forman MR, Beecher GR, Lanza E (1995): Effect of alcohol consumption on plasma carotenoids concentrations in premenopausal women: a controlled dietary study.Am J Clin Nutr 62: 131-135
  12. Friedewald WT. Levy RI, Fredrickson DS (1972): Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
  13. Herbrth B, Spyckerelle Y, Deschamps J (1999): Determinants of plasma retinol, beta-carotene, and alpfa-carotene during adolescent. Am J Clin Nutr 54: 884-889
  14. Lee HJ, Park SJ, Kim JH, Kim ci Chang KJ, Yim KS, Kim K, Choi H (2002): Development and Validation of Semi-Quantitative Food Frequency Questionnaire for Evaluating Nutritional Status of 50yr and Older Subjects in Korean. J Comm Nutr 7 (2): 277-285
  15. Lee HJ, Park SJ, Kim JH, Kim CI, Chang KJ, Yim KS, Kim K, Choi H (2003): Evaluating Nutrient intakes of Korean elderly Using SemiQuantitative Food Frequency Questionnaire. J Comm Nutr 8 (3): 311-318
  16. Hof KH, West CE, Weststrste JA, Hautvast JGAJ (2000): Dietary Factors that Affect the bioavailability of carotenoids. J Nutr 130: 503-506
  17. Jo JO, Jung IC (2000): Changes in carotenoid contents of several greenyellow vegetables by blanching korean.J Soc Food SCI 16(1): 17-21
  18. Kim CI (2002): Factors limiting food intake in elderly and their countermeasures Proceedings of 2nd International Symposium on 'Nutritional Management for the Elderly', pp.99-116
  19. Kostic D, White WS, Olson JA (1995): Intestinal absorption, serumclearanee, and interaction between lutein and beta-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr 62: 604-610
  20. Leo MA, Kim CL, Lowe N, Lieber CS (1992): Interaction of ethanol with beta-carotene: delayed blood clearance and enhanced hepatotoxicity. Hepatology 15: 883-891
  21. Michaud DS, Feskanich D, Rimm EB, Colditz GA, Speizer FE, Willett WC, Giovannucci E (2000): Intake of specific carotenoids and of lung cancer in 2 prospective US cohorts. Am J Clin Nutr 72: 990-997
  22. Ministry of Health & Welfare (2002): 2001 National Health and Nutrition Survey -Chronic diseases-
  23. Nishino H, Tokuda H, Satomi Y, Masuda M, Bu P, Onozuka M, Yamaguchi S, Okuda Y, Takayasu J, Tsuruta J, Okuda M, Ichiishi E, Murakoshi M, akasuka N, Yano M (1999): Cancer prevention by carotenoids. Pure Appl Chem 71: 273-2278
  24. Owen AL, Splett PL, Owen GM (2000): Nutrition in the community (4th edition). WBC McGraw-Hill press
  25. Paetau I, Chen H, Goh NMY (1997): Interaction in the postprandial appearance of beta-carotene, canthaxanthin in plasma triacylglycerol rich lipoproteins in human. Am J Clin Nutr 66: 1133-1143
  26. Pamuk ER, Byers T, Coates Rj (1994): Effect of smoking on serum nutrient concentrations in African-American Women. Am J Clin Nutr 59: 891-895
  27. Park DK (1994): Antioxidant activity of beta-carotene related carotenoids of peroxyl radical mediated lipid peroxidation. J Biochem Mol Bio 27: 479-483
  28. Parker RS. Swanson JE, You CS, Edwards AJ, Huang T (1999): Bioavailability of carotenoids in human subjects. Proc Nutr Soc 58: 155-162 https://doi.org/10.1079/PNS19990021
  29. Riedl J, Linseisen J, Hoffmann J, Wolfram G (1999): Some dietary fiber reduce the absorption of carotenoids in Women. J Nutr 129: 2170-2176
  30. Rock CL, Thomquist MD, Kristal AR, Patterson RE, Cooper D, Neuhouser ML, Neumark-Sztainer D, Cheskin LJ (1999): Demographic, dietary and lifestyle factor differentially explan variability in serum carotenoids and fat-soluble vitamins: baseline results from the Olestra Post-Marketing Surveillance Study. J Nutr 129: 855-864
  31. Roodenburg AJ, Leenen R, van het Hof K, Westrate JA, Tijburg LB (2000): Amount of fat in diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene and vitamin E in humans. Am J Clin Nutr 71: 1187-1193
  32. Smith TA (1998): Carotenoids and cancer: prevention and potential therapy. Br J Biomed Sci 55: 268-275
  33. Stahl W, Sies H (1992): Uptake of Iycopene and its geometrical isoners is greater from heat-processed than from unprocessed tomato juice in human. J Nutr 122: 2161-2166
  34. Stryker WS, Kaplan LA, Stein EA, Stampfer MJ, Sober A, Willet WC (1988): The relation of diet cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. Am J Epidemiol 127: 283-296 https://doi.org/10.1093/oxfordjournals.aje.a114804
  35. Terry P, Jain M, Miller AB, Howe GR, Rohan TE (2002): Dietary carotenoids and risk of breast cancer. Am J Clin Nutr 76: 883-888
  36. Van Poppel G (1996): Epidemiological evidence for $\beta$ -carotene in prevention of cancer and cardiovascular disease. Eur J Clin Nutr 50: s57-s61
  37. Vile GF, Winterboum CC (1988): Inhibitor of adriamycin promoted microsomal lipid peroxidation by $\beta$-carotene, $\alpha$-carotene and retinol at high and low oxygen partial pressure. FEBS Letter 238: 353-356 https://doi.org/10.1016/0014-5793(88)80511-8
  38. White E, Kristal AR, Shikany JM, Wilson AC, Chen C, Mares-Perlman JA, Masakii KH. Caan BJ (2001): Correlates of serum alpha- and gamma-tocopherol in women's health initiative. Ann Epidemiol 11: 136-144
  39. Whittaker P, Wamar WG, Chanderbhan RF, Dunkel VC (1996): Effects of alpfa-tocopherol and $\beta$-carotene on hepatic lipid peroxidation and blood lipids in rats with dietary iron overload. Nutr & Can 25: 119-128 https://doi.org/10.1080/01635589609514434