Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Influence of Bornyl Acetate on Blood Pressure and Aortic Strips Contractility of the Rat

  • Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Ki, Young-Woo (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Na, Gwang-Moon (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kang, Moo-Jin (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kim, Byeoung-Cheol (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kim, Ok-Min (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Hong, Soon-Pyo (Department of Internal Medicine (Cardiology), College of Medicine, Chosun University)
  • Published : 2003.06.01
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Abstract

The present study was conducted to investigate the effects of bornyl acetate on arterial blood pressure and vascular contractile responses in the normotensive rats and to establish the mechanism of action. Both phenylephrine (an adrenergi$\alpha$-receptor agonist) and high potassium (a membrane-depolarizing agent) caused greatly contractile responses in the isolated aortic strips. These phenylephrine (10$^{-5}$ M)-induced contractile responses were depressed in the presence of high concentrations of bornyl acetate (10∼20 $\mu\textrm{g}$/ml), but not affected in low concentrations of bornyl acetate (2.5∼5$\mu\textrm{g}$/ml). High potassium (5.6 ${\times}$ 10$^{-2}$ M)-induced contractile responses were also greatly inhibited in the presence of bornyl acetate (2.5∼20 $\mu\textrm{g}$/ml) in a dose-dependent fashion. Bornyl acetate (1∼10 mg/kg) given into a femoral vein of the normotensive rat produced a dose-dependent depressor response, which is transient (data not shown). Interestingly, the infusion of a moderate dose of bornyl acetate (3mg/kg/30 min) made a significant reduction in pressor responses induced by intravenous norepinephrine. Collectively, these results obtained from the present study demonstrate that intravenous bornyl acetate causes a dose-dependent depressor action in the anesthetized rat at least partly through the blockade of adrenergic $\alpha$$_1$-receptors. bornyl acetate also causes vascular relaxation in the isolated aortic strips of the rat via the blockade of adrenergic $\alpha$$_1$-receptors, in addition to the unknown mechanism of direct vasorelaxation.

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References

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