DOI QR코드

DOI QR Code

Antiobesity Effects of Platycodon grandiflorum Extract on Body Weight Changes and Serum Lipid Profiles of Obese Rats Induced High Fat Diet

도라지 추출물의 항비만 효과: 비만 흰쥐 체중변화와 혈청 Lipid Profile에 대한 도라지 추출물의 영향

  • Published : 2003.12.01

Abstract

The present study was carried out to investigate the antiobesity effects of Platycodon grndiflorum extract on body weight changes and serum lipid composition of rats fed high fat diet. The Platycodon grandiflorum has been widely used as a folk food in the Orient for many centuries. We had experiment with Platycodon grandiflorum extract in order to find cure effects for obesty. The changes of the body weights in Platycodon ggrandiflorum extract treatment group showed a decrease in comparison with control group. Weekly body weights of PG group are respectively 243.7$\pm$2.0g, 283.5$\pm$4.3 g, 310.5$\pm$6.5 g, 333.2$\pm$7.5 g, 361.0$\pm$10.4 g, 390.5$\pm$11.5 g, 436.0$\pm$11.8 g, 454.4$\pm$11.4 g, 484.4$\pm$10.1 g. Body weight of PC groups are decreased compared with those of control group, but the rates are not significant. Total cholesterol of PG group(77.2$\pm$3.3 mg/dl) is decreased by 7.0% compared with that of control group. Serum triglyceride of PG group(103.6$\pm$9.0mg/dl) is decreased by 21.1% compared with that of control group. Serum free fatty acid of PG group(630.1$\pm$45.9 $\mu$Eq/l) is decreased by 19.6% .compared with that of control group. Total lipid amount of PG group(393.6$\pm$23.7 mg/dl) is decreased by 9.1% compared with that of control group. The above results suggest that Platycodon grandiflorum extract could prevent or cure metabolic diseases by preventing hyperlipemia caused by high fat diet.

본 연구는 도라지 추출물의 항 비만 효과를 관찰하기 위하여 비만 흰쥐에 도라지 추출물을 투여 한 후, 비만 흰쥐의 체중 변화와 혈청 중의 지질 프로파일을 측정하였다. 그 결과 도라지 추출물의 투여는 실험 시작 후 1주부터 8주까지 대조군에 비하여 감소하는 경향을 보였다. 고지방식이로 비만을 유도하였을 때, 정상군 보다 total cholesterol, triglyceride, fatty acid, total lipid의 함량이 증가되던 것이 도라지 추출물의 투여로 total cholesterol, triglyceride, fatty acid, total lipid의 함량이 현저히 감소하는 경향을 나타냈다. PG군의 total cholesterol$(77.2\pm3.3mg/dl)$은 대조군에 비해 약 7.0% 감소되었으며, PG군의 triglyceride$(103.6\pm9.0 mg/dl)$은 대조군에 비해 약 21.1% 감소되었다. 아울러 PG군의 fatty acid$(630.1\pm45.9 uEq/L)$함량은 대조군에 비해 약 19.6% 감소하였다. 또한 PC군의 경우 총 지질 함량은 $396\pm23.7mg/dl$ 이며, 이는 대조군에 비해 약 9.1% 감소하는 경향을 나타냈다. 이상의 결과로 미루어 보아 도라지 추출물은 비만의 개선 효과가 있을 것으로 생각되며, 앞으로 많은 연구가 병행하여야 할 것으로 사료된다.

Keywords

References

  1. Medicine Adult disease · Geriatrics Seo,S.G.
  2. J. Eur. Heart v.8 Strategies for prevention of coronary heart disease: A policy statement of the European Athrosclerosis Society European Athrosclerosis Society
  3. Clinical Laboratory Methods and Diagnosis(Revision 3rd.) Editing Committee for translation Kanai,I.;Kanai,M.
  4. Effects of Nutrition education in weitht management program Choue,R.W.;Y.J.Hong;H.W.Lee;S.L.Lee
  5. J. Food Sci. Nutr. v.22 Relationships of Obesity in Childhood to Plasma Lipids, Blood Pressure and Blood Glucose Lim,H.S.;Lee,J.I.
  6. Circulation v.67 Obesity as an independent risk factor for cardiovascular disease: A 26-year follow up of participants in the Framinfham heart study Hurbert,H.B.;Feinleib,M.;McNamara,P.M.
  7. Harrison's Principles of internal medicine(13th ed.) Isselbacher Kurt,J.
  8. J. Psycosom Res. v.7 A comparison of the psychological adjustment of obese versus nonobese children Sallade,J.
  9. Obesity is shortening to life Nakamura,H.
  10. Kampo-therapy of adult disease v.8 Terasi Bokuso
  11. Am. J. Clin. Pathol. v.53 A colorimetric method for determination of total serum lipids based on the sulfo-phospho-vanillin reaction Frings,C.S.;Dunn,R.T.
  12. J. Lipid Res. v.11 Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions Burstein,M.
  13. A Study on Examination Results by Obesity index among Visitors of a Comprehensive health screening Center In Pusan Chai,Young-hee
  14. Serum Lipid Profiles and Diet patterns in Obese children in Seoul v.3 Kang,Y.J.;Park,H.S.;Shin,E.S.
  15. Am. J. Clin. Nutr. v.62 Relation of weight loss to change in serum lipids and lipoproteins in obese women Ross,E.A.;Thomas,A.W.;Susan,J.B.;Renee,A.V.;Ruth,S.W.

Cited by

  1. Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae vol.47, pp.1, 2015, https://doi.org/10.9721/KJFST.2015.47.1.111
  2. Changes in Platycoside Components and Antimicrobial Activities of Bronchus Disease-Inducing Bacteria of Fermented Platycodon grandiflorum Root by Lactic Acid Bacteria vol.45, pp.7, 2016, https://doi.org/10.3746/jkfn.2016.45.7.1017
  3. on degranulation and inflammatory mediator release in RBL-2H3 cells vol.51, pp.3, 2018, https://doi.org/10.4163/jnh.2018.51.3.208