Journal of Embryo Transfer (한국수정란이식학회지)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Effect of PN Grade on Subsequent Development In Vitro of Human Embryos

사람에서 전핵 등급이 체외수정란의 발달에 미치는 영향

  • B. G. Jeon (Kaya Mother-Child's Hospital) ;
  • Lee, S. L. (Institute of Animal Science, College of Veterinary Medicine, Gyeongsang National University) ;
  • S. A. Ock (Department of Biology, Gyeongsang National University) ;
  • Kim, K. S. (Kaya Mother-Child's Hospital) ;
  • J. S. Moon (Kaya Mother-Child's Hospital) ;
  • D. O. Kwack (Department of Biology Education, Gyeongsang National University) ;
  • Park, G. J. (Institute of Animal Science, College of Veterinary Medicine, Gyeongsang National University) ;
  • S. Y. Choe (Institute of Animal Science, College of Veterinary Medicine, Gyeongsang National University)
  • Published : 2003.08.01
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Abstract

본 연구는 사람의 시험관아기 프로그램에서 수정 후 1일째의 전핵 등급이 체외 수정란의 발달에 미치는 영향을 조사하였다. 정상적인 시험관 아기 시술을 시행한 실례 환자를 대상으로 과배란을 유기하여 배란 직전의 난자를 채취하여 정자를 주입한 다음 체외 수정을 유도하였다. 수정 유도 18시간 후 전핵과 핵인의 형태에 따라 전핵의 등급을 1 및 2등급으로 나누어 각각 3일 동안 체외 배양을 실시하여, 체외 수정란의 형태에 따라 1, 2 및 3등급으로 분류하였든 바, 전핵의 등급에 따라 각각 1등급 체외수정란의 발달율은 1등급 전핵란에서는 83.5%로서 2등급 전핵란의 5.5%보다 유의적으로 (P<0.05) 높았다. 1등급 및 2등급 전핵란에서 수정 후 3일째에 5-세포기 이상의 단계로 발달하는 경우는 각각 85.1% 및 24.5%를 나타내었고, 평균 할구수는 7.4$\pm$2.1 및 4.1$\pm$3.5개를 나타내어 발달 능력에서 1등급 전핵란이 2등급 전핵란보다 유의적으로 (P<0.05) 높게 나타났다.

Keywords

References

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