Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지
DOI QR코드

DOI QR Code

Comparisons of Antidiabetic Effect between Ginseng Radix Alba, Ginseng Radix Rubra and Panax Quinquefoli Radix in MLD STZ-induced Diabetic Rats

Multiple Low Dose Streptozotocin으로 유도된 당뇨 흰쥐에서 백삼, 홍삼, 화기삼의 항당뇨 활성 비교

  • 박경수 (경희대학교 약학대학 약물학교실) ;
  • 고성권 (중앙대학교 인삼산업연구센터) ;
  • 정성현 (경희대학교 약학대학 약물학교실)
  • Published : 2003.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was designed to compare the antidiabetic activities between Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR) and Panax Quinquefoli Radix (PQR) in multiple low dose (MLD) streptozotocin (STZ) (20 mg/kg i.p injection far 5 days) induced diabetic rats. In the glucose tolerance test, 500 mg/kg of each ginseng ethanol extract was administered intraperitoneally 30 min before glucose challenge. While GRA failed to lower blood glucose level, GRR and PQR both significantly prevented the hyperglycemia when compared with the control group. In the MLD STZ-induced diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as far as blood parameters and diabetic symptoms such as polyphagia and polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenosides were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT): proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia effects.

복강 내당능 시험과 MLD STZ 당뇨를 유발시킨 rat에서 백삼, 홍삼, 화기삼의 항당뇨 활성을 비교한 결과를 요약하면 다음과 같다. 1. 복강 내당능 시험에서 백삼은 효과를 나타내지 못한 반면 홍삼과 화기삼은 대조군에 대하여 유의적인 변차를 나타내었다. MLD STZ로 당뇨를 유발시킨 SD계 흰쥐에 백삼, 홍삼, 화기삼을 2주간 투여 후 혈당강하 활성을 비교한 결과 홍삼 투여군의 혈당이 가장 낮았으며 백삼과 화기삼은 비슷한 크기의 활성을 나타내었다. 2. 백삼과 홍삼, 화기삼은 모두 고혈당에 의한 체중 감소 현상을 개선시켰으며 각 투여군 간에는 유의적인 차이는 없었다. 3. 당뇨의 대표적인 증상인 다식 (多食)과 다음 (多飮)현상이 백삼, 홍삼, 화기삼 투여에 의하여 개선되었으며 그 중 홍삼에 의한 효과가 가장 컸다. 4. 혈당강하 활성과 ginsenoside profile간의 상관관계를 살펴본 결과 PPT/PPD ratio가 가장 큰 홍삼의 혈당강하 활성이 백삼과 화기삼에 비해 높은 것으로 보아 PPT/PPD ratio가 혈당강하 활성의 key ratio가 아닌가 추측된다.

Keywords

References

  1. Morkdad, A. H. Ford, E. S. Bowman, B. A. Nelson, D.E. Engelgau, M. M. Victor, F. and Marks, J. S. : Diabetes Care 23, 1278 (2000) https://doi.org/10.2337/diacare.23.9.1278
  2. Sorensen, T. T.: Diabetes Care 23(suppl 2), Bl (2000) https://doi.org/10.2337/diacare.23.1.1
  3. Sotaniemi, E. A. Haapakoski, E. and Rautio, A. : Diabetes Care 18, 1373 (1995) https://doi.org/10.2337/diacare.18.10.1373
  4. Vuksan, V. Sievenpiper, J. L. Koo, V. Y. Y. Francis, T. Beljan-Zdravkovic, U. Xu, Z. and Vidgen, E. : Arch Intern Med 160, 1009 (2000) https://doi.org/10.1001/archinte.160.7.1009
  5. Vuksan, V. Leiter, A.L. Stavra, M. B. Josse, R. G. Seivenpiper, J. L. Xu, Z. and Beljan-Zdravkovic, U. Diabetes Care 23, 1221 (2000) https://doi.org/10.2337/diacare.23.9.1221
  6. Vuxsan, V. Sievenpiper, J. L. Wong, J. Xu, Z. Beljan-Zdravkovic, U. Arnason, J. T. Assinewe, V. Stavro, M. P. Jenkins, A.L. Leiter, L. A. and Francis, T. : Am J Clin Nutr 73(4), 753 (2001) https://doi.org/10.1093/ajcn/73.4.753
  7. Sievenpiper, J. L. Arnason, J. T. Leiter, L. A. and Vuksan, V. : Eur J Clin Nutr 57(2), 243 (2003) https://doi.org/10.1038/sj.ejcn.1601550
  8. Konno, C. Sugimyama, K. Kano, M. and Hikino, H. : Planta Med 50, 434 (1984) https://doi.org/10.1055/s-2007-969757
  9. Yokozawa, T. Kobayashi, T. Kawai, A. Oura, H. and Kawashima, Y.: Chem Pharm Bull 32, 2766 (1984) https://doi.org/10.1248/cpb.32.2766
  10. Oshima, Y. Konno, C. and Hikino, H. : J Ethnopharmacol 14, 255 (1985) https://doi.org/10.1016/0378-8741(85)90091-1
  11. Oshima, Y. Sato, K. and Hikino, H.: J Nat Prod 50, 188 (1987) https://doi.org/10.1021/np50050a010
  12. Park, K. S. Lee, D. E. Sung, J. H. and Chung, S. H. : J Ginseng Res 26(4), 191 (2002) https://doi.org/10.5142/JGR.2002.26.4.191
  13. Trinder, P.: Ann. Clin. Biochem. 6, 24 (1969) https://doi.org/10.1177/000456326900600108
  14. Bonfill, M. Casals, I. Palazon, J. Mallod, A. and Morales, C. : Biomed Chromatogr 16, 68 (2002) https://doi.org/10.1002/bmc.120.abs
  15. Attele, A. S. Zhou, Y. P. Xie, J. T. Wu, J. A. Zhang, L. Dey, L. Pugh, W Rue, P. A. Polonsky, K. S. and Yuan, C. S. : Diabetes 51, 1851 (2002) https://doi.org/10.2337/diabetes.51.6.1851

Cited by

  1. Effects of Goat Milk Yogurt Supplemented with Citrus Concentrate on Blood Glucose and Serum Lipids in Diabetic Rats vol.28, pp.4, 2008, https://doi.org/10.5851/kosfa.2008.28.4.445
  2. Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials vol.17, pp.12, 2011, https://doi.org/10.1007/s11655-011-0937-2
  3. Roots: A Comparative Study vol.30, pp.2, 2014, https://doi.org/10.1080/87559129.2014.883631
  4. vol.49, pp.1, 2016, https://doi.org/10.4163/jnh.2016.49.1.18
  5. vol.21, pp.3, 2018, https://doi.org/10.1089/jmf.2017.3939