Biomedical Science Letters (대한의생명과학회지)
- Volume 9 Issue 1
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- Pages.51-58
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- 2003
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Protective Effect of Panax ginseng on TCDD-induced Liver Toxicity in Male Guinea Pigs
- Hwang, Seock-Yeon (Department of Clinical Pathology, Chungbuk National University Hospital, Cheongju) ;
- Wee, Jae-Joon (Department of Ginseng Pharmacology Research, KT&G Central Research Institute) ;
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Kim, Si-Kwan
(College of Natural Science, Konkuk University) ;
- Youn, Nae-Young (Department of Obstetrics and Gynecology, College of Medicine)
- Published : 2003.03.01
Abstract
This study was carried out to investigate the preventive and therapeutic effect of Panax ginseng water extract (PG-WE) on the toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), one of the most notorious toxic environmental pollutants belonging to the group of polyhalogenated aromatic hydrocarbons. Normal control (NC) group guinea pigs (180~200 g) received vehicle and saline, and TCDD-treated (TT) group was given TCDD and saline. P100 and P200 group animals received PG-WE for 28 days since 1 week before TCDD exposure at daily doses of 100 mg/kg b.w. and/or 200 mg/kg b.w., respectively. C100 and C200 group received PG-WE for 14 days starting 1 week after TCDD-exposure. Toxicity was induced by a single intraperitoneal injection of TCDD (1
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