Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Effect of Green Tea on Radion-induced Late Biological Effect in Mice

감마선을 조사 한 마우스에서 녹차 장기투여의 효과

  • Kim, Se-Ra (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Hae-Jun (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Hyu-Kyung (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Jin-Hee (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Ki-Seok (College of Veterinary Medicine, Chonnam National University) ;
  • Park, In-Chul (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Heon (Korea Atomic Energy Research Institute) ;
  • Cho, Sung-Ki (Korea Atomic Energy Research Institute) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
  • Published : 2003.06.01
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Abstract

This study was performed to determine the effect of green tea on the late biological effect (survival, hematological change, carcinogenesis) of mice irradiated with 3 Gy of gamma-radiation. There was little difference in body weights between normal and irradiated mice. Survival rate were decreased in irradiated mice and the survival rate and mean survival time of the groups treated with green tea were far better than the irradiation control group. An elevation of mean number of total leukocyte or lymphocyte counts was seen at week 12 of the group treated with green tea. Stimulated recovery by the extract from green tea was also observed in thrombocyte. Main gross findings of irradiated mice were appeared as enlargement of spleen, thymus and liver, tumorous nodules in lung and cyst or mass in ovary. Microscopically, there were various findings including hematopoietic and lymphoid tumor, lung cancer, ovarian cancer and cancer of other lesions. Green tea reduced the incidence of tumor development. Further studies are needed to characterize better the protective nature of active compounds.

Keywords

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