No Association of the Human Y Chromosome with Blood Pressure in Korean Male Population

  • Published : 2003.03.01

Abstract

It has been reported that the genetic variations in the Y chromosome has influence the blood pressure in some Caucasian male populations, but the effect in non-Caucasian population is unclear. In the present study, we examined the relationship between blood pressure and a HindIII RFLP of Y chromosome in 152 unrelated male individuals of ethnically homogeneous Korean origin. There were no significant differences in systolic and diastolic blood pressures between genotype groups, respectively. However, the frequency of A genotype in Korean population was much higher than those of Caucasian populations (P<0.05). Therefore, the results of this study will con-tribute the better understanding the genetic characteristics of Y chromosome in Korean population.

Keywords

References

  1. Hypertension v.39 The Y chromosome effect on blood pressure in two European populations Charchar,F.J.;Tomaszewski,M.;Padmanabhan,S.;Lacka,B.;Upton,M.N.;Inglis,G.C.;Anderson,N.H.;McConnachie,A.;Zukowska-Szczechowska,E.;Grzeszczak,W.;Connell,J,M,C,;Watt,G.C.M.;Dominiczak,A.F. https://doi.org/10.1161/hy0202.103413
  2. Hypertension v.26 Blood pressure in genetically hypertensive rats:influence of the Y chromosome Davidson,A.O.;Schork,N.;Jaques,B.C.;Kelman,A.W.;Sutcliffe,R.G.;Reid, J.L.;Domniczak,A.F. https://doi.org/10.1161/01.HYP.26.3.452
  3. Hypertension v.36 Association of the Human Y chromosome with high blood pressure in the general population Ellis,J.A.;Stebbing,M.;Harrap,S.B. https://doi.org/10.1161/01.HYP.36.5.731
  4. Hypertension v.16 Hypertension in the spontaneously hypertensive rat is linked to the Y chromosme Ely,D.L.;Turner,M.E https://doi.org/10.1161/01.HYP.16.3.277
  5. Braz. J. Med. Biol. Res. v.33 A review of the Y chromosome and hypertension Ely,D.L.;Turner,M.E.;Milsted,A. https://doi.org/10.1590/S0100-879X2000000600009
  6. Bioessays v.17 The origin and function of the mammalian Y chromosome and Y-borne genes: an evolving understanding, Graves,J.A. https://doi.org/10.1002/bies.950170407
  7. Hypertension v.37 Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR Kren,V.;Qi,N.;Krenova,D.;Zidek,V.;Sladka,M.;Jachymova,M.;Mikova,B.;Horky,K.;Bonne,A.;Van Lith,H.A.;Van Zutphen,B.F.;Lau,Y.F.;Pravenec,M.;St.Lezin,E. https://doi.org/10.1161/01.HYP.37.4.1147
  8. Hypertension v.28 The Y chromosome: epistatic and ecogenetic interactions in genetic hypertension Kreutz,R.;Stock,P.;Struk,B.;Lindpaintner,K. https://doi.org/10.1161/01.HYP.28.5.895
  9. Proc. Natl. Acad. Sci. USA v.74 Analysis of human Y chromosome-specific reiterated DNA in chromosome variants Kunkel,L,M.;Smith,K.D.;Boyer,S.H.;Borgaonkar,D.S.;Wachtel,S.S.;Miller,O.J.;Breg,W.R.;Jones,H.W.;Rary,J.M. https://doi.org/10.1073/pnas.74.3.1245
  10. Hypertension v.37 Reciprocal consomic strains to evaluate Y chromosome effects Negrin,C.D.;McBride,M.W.;Carswell,H.V.;Graham,D.;Carr,F.J.;Clark,J.S.;Jeffs,B.;Anderson,N.H.;Macrae I.M.;Dominiczak,A.F. https://doi.org/10.1161/01.HYP.37.2.391
  11. Hypertension v.37 Gender differences in the regulation of blood pressure Reckelhoff,J.F. https://doi.org/10.1161/01.HYP.37.5.1199
  12. Gene v.165 PCR haplotypes for the human Y chromosome based on alphoid satellite DNA variants and heteroduplex analysis Santos,F.R.;Pena,S.D.J.;Tyler-Smith, C. https://doi.org/10.1016/0378-1119(95)00501-V