Construction and Operation of a 37-channel Hemispherical Magnetoencephalogram System

37채널 반구형 뇌자도 측정장치 제작 및 동작

  • 이용호 (한국표준과학연구원 초전도그룹) ;
  • 김진목 (한국표준과학연구원 초전도그룹) ;
  • 권혁찬 (한국표준과학연구원 초전도그룹) ;
  • 김기웅 (한국표준과학연구원 초전도그룹) ;
  • 박용기 (한국표준과학연구원 초전도그룹) ;
  • 강찬석 (고려대학교 물리학과) ;
  • 이순걸 (고려대학교 물리학과)
  • Published : 2003.06.01

Abstract

We developed a 37-channel magnetoencephalogram (MEG) measurement system based on low-noise superconducting quantum interference device (SQUID) magnetometets, and operated the system to measure MEG signals. By using double relaxation oscillation SQUIDs with high flux-4o-voltage transfers, the SQUID outputs could be measured directly by room temperature preamplifiers and compact readout circuits were used for SQUID operation. The average field noise level of the magnetometers is about 3 fT/√Hz in the white region, low enough for MEG measurements when operated inside a magnetically shielded room. The 37 magnetometers were distributed on a hemispherical surface haying a radius of 125 mm. In addition to the 37 sensing channels. 11 reference channels were installed to pickup external noise and to form software gradiometers. A low-noise liquid helium dewar was fabricated with a liquid capacity of 30 L and boil-off rate of 4 L/d. The signal processing software consists of digital filtering, software gradiometer, isofield mapping and source localization. By using the developed system, we measured auditory-evoked fields and localized the current dipoles, demonstrating the effectiveness of the system.

뇌자도 측정을 위해 고감도 superconducting quantum interference device (SQUID) 자력계 및 37채널 뇌자도 측정장치를 제작하고 동작특성을 조사하였다. 자속-전압 변환계수 및 변조전압 진폭이 큰 double relaxation oscillation SQUID (DROS)를 사용함으로서 구동회로를 간단히 하였고 안정한 SQUID 동작을 실현할 수 있었다. DROS 자력계를 설계 및 제작한 결과 자력계의 평균 백색잡음은 약 3 fT/√Hz으로서 우수한 자장감도를 가짐을 확인하였다 머리의 평균곡률을 기반으로 37개의 자력계를 반구형으로 배치시켰으며, 외부잡음을 줄이기 위해 신호채널 외에 11개의 기준채널을 설치하여 소프트웨어 방법으로 합성미분계 및 적응필터링을 형성할 수 있도록 하였다 저잡음 듀아를 제작하여 동작특성을 측정한 결과 듀아 열자기 잡음이 자력계 잡음에 비해 무시할 수 있는 수준이었으며, 듀아의 용량은 30 L, 액체헬륨 증발율은 4 L/d이다. 제작된 시스템을 이용하여 청각유발 신호를 측정하고, 디지털 신호처리 및 전류원 국지화 프로그램을 구성하여 전류원의 위치를 추정함으로서 개발된 시스템을 뇌자도 측정에 활용하였다.

Keywords

References

  1. Rev. Mod. Phys. v.65 no.2 Magnetoencephaography theory, instrumentation, and applications to noninavasive studies of the working human brain M.Hamalainen(et al.)
  2. 12th Int'l Conf. Biomagnetism
  3. 13th Int'l Conf. Biomagnetism
  4. SQUID Sensors : Fundamentals, Fabrication and Applications, Dordrecht J.Vrba
  5. Supercond. Sci. Technol. v.14 Multichannel applications of double relaxation oscillation SQUIDs Y.H.Lee;H.C.Kwon;J.M.Kim;Y.K.Park
  6. IEEE Trans. Appl. Supercond. v.4 no.3 Recent Law Temperature SQUID Developments D.Drug.
  7. J. Appl. Phys. v.76 no.6 (Double)relaxation oscillation SQUIDs with high flux-to-voltage transfer: Simulations and experiments D.J.Adelerhof;H.Nijstad;F.Flokstra;H.Rogalla
  8. J. Kor. Phys. Soc. v.38 no.6 Localization error of a 150-channel whole-cortex magnetoencephalography system J.W.Lee;Y.H.Lee;S.C.Jun;H.C.Kwon
  9. IEEE Trans. Appl. Supercond A Multichannel SQUID Magnetometer System Based on Double Relaxation Oscillation SQUIDs Y.H.Lee;H.Kwon;J.M.Kim;C.S.Kang;K.Kim;I.S.Kim;Y.K.Park;S.G.Lee
  10. J. Kor. Mag. Soc. v.6 no.4 Construction an Performance of Magnetically Shielded Room for Biomagnetic Applications Y.H.Lee;H.C.Kwon;J.M.Kim;C.M.Lim;S.K.Lee;Y.K.Park;J.C.Park
  11. Prog. Supercond. v.4 no.1 Programmatic Sequences for the Automatic Adjustment of Double Relaxation Oscillation SQUID Sensors K.Kim;Y.H.Lee;H.Kwon;J.M.Kim;C.S.Kang;I.S.Kim;Y.K.Park
  12. Phys. Med. Bio. v.47 Localization accuracy of single current dipoles from tangentai components of auditory evoked fields. H.Kwon;Y.H.Lee;J.M.Kim;Y.K.Park;S.Kuriki
  13. IEEE Trans. Biomed. Eng. Submitted Correction in the Principal Component Elimination Method for Excluding Correlated Noises in Neuromagnetic Evoked Field Measurements K.Kim;Y.H.Lee;H.Kwon;J.M.Kim;C.S.Kang;Y.K.Park;I.S.Kim
  14. KRISS Research Report, KRISS/IR 2000-094 Development of MEG measurement using SQUID Y.H.Lee(et al.)
  15. ASA Program