한국환경보건학회지 (Journal of Environmental Health Sciences)

  • 제29권2호
  • /
  • Pages.29-37
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  • 2003
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  • 1738-4087(pISSN)
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  • 2233-8616(eISSN)
한국환경보건학회 (Korean Society of Environmental Health)
권호 표지

유방암 환자와 정상여성의 혈액 및 지방조직 중 PCBs 형태에 관한 연구

The Pattern of PCBs Level in Adipose Tissue and Serum of Breast Cancer and Normal Women

  • 노영만 (가톨릭대학교 의과대학 산업의학센터) ;
  • 이강숙 (가톨릭대학교 의과대학 산업의학센터) ;
  • 구정완 (가톨릭대학교 의과대학 산업의학센터) ;
  • 장경순 (가톨릭대학교 의과대학 산업의학센터)
  • 발행 : 2003.06.01
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초록

The purpose of this study was to identify the distribution of non-ortho and mono-ortho PCB congeners and homologues in adipose tissues and sera of women with breast cancer. The collected samples were 25 adipose tissues and 33 sera from women with breast cancer. The samples from the control group were 49 adipose tissues and 52 sera. The levels of three non-ortho and eight mono-ortho PCBs identified in adipose tissue and serum samples were determined by GC/MSD and GC/ECD analyses. Non-ortho and mono-ortho PCB congeners were more dominant in the control group than in the case group for serum samples. The Tetra-PCB and the Hexa-, Hepta-PCB were more dominant in tale and control groups, respectively. The level of PCB homologues in normal women was similar to that of the normal human milk samples. However, the levels of PCB homologues from breast cancer patients were almost same the level of sample from environment. As a result of this study, it is suggested that breast cancer could be related to environmental factors such as PCB level in stack gas and soil sample. More extended research should be to verify this result.

키워드

참고문헌

  1. Safe, S. : Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ Health Perspect, 100, 259-268, 1992 https://doi.org/10.2307/3431532
  2. 공샛별, 조병환, 장윤석 : 국내 환경시료중에 존재하는 PCBs의 농도와 분포특성. 대한 환경공학회지, 21(11), 2131-2141, 1999
  3. Eric J. Willman, Jon B. Manchester-Neesvig, David E. Armstrong : Influence of ortho-Substitution on patterns of PCB Accumulation in Sediment, Plankton, and Fish in a Freshwater Estuary. Environmental Science & Technology, 31, 3712-3718, 1997 https://doi.org/10.1021/es970533g
  4. Walker, M. K. and Peterson, R. E. : Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, for producing early life stage mortality in rainbow trout, Aquat. Toxicol, 21, 219-238, 1991 https://doi.org/10.1016/0166-445X(91)90074-J
  5. 양윤희, 장윤석, 김병훈, 양지연, 신동천 : 국내 모유에서의 PCBs 및 PCDD/Fs 분포특성과 위해성 평가. Analytical Science &Technology, 13(4), 520-533, 2000
  6. Mueller, G. C. and Kim, U. H. : Displacement of estradiol from estrogen receptors by simple alkylphenols. Endocrinology, 102, 1429-1435, 1978 https://doi.org/10.1210/endo-102-5-1429
  7. Hirsh, J. H. and Schwartz, T. R. : Determination, Fate, and Potential Signiticance of PCBs in Fish and Sediment Samples with Emphasis on Selected Ahhinducing Congeners. Chemosphere, 17(10), 1995-2016, 1998 https://doi.org/10.1016/0045-6535(88)90011-2
  8. Cooper, R. L. and Kavlock, R. J. : Endocrine disruptors and reproductive development: a weight-of-evidence overview. J Endocrinol, 152, 159-166, 1997 https://doi.org/10.1677/joe.0.1520159
  9. White, R.. Jobling, S., Hoare, S. A., Sumpter. J. P. and Parker, M. G. : Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology, 135, 175-182, 1994 https://doi.org/10.1210/en.135.1.175
  10. Davis, D. L., Telang, N. T., Osborne, M. P. and Bradlow, H. L. : Medical hypothesis bifunctional genetic -honnonal pathways to breast cancer. Environ Health Perspect 105(suppppl 3), 571-576, 1997 https://doi.org/10.1289/ehp.97105s3571
  11. Wolf, M. S., Rivera, M. and Baker, D. B. : Detection limits of organochlorine pesticides and related compounds in blood serum. Bull Environ Cotam Toxicol, 47, 499-503, 1991 https://doi.org/10.1007/BF01700936
  12. Bucholski, K. A., Begerow, J., Winnek, G. and Dunemann, L. : Detennination of polychlorinated biphenyls and chlorinated pesticides in human body fluids and tissues. J. Chromatogr A, 754, 479-485, 1996 https://doi.org/10.1016/S0021-9673(96)00344-5
  13. Safe, S. and Phin, D. : Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins(PCDDs), Dibenzofurans (PCDFs), and Related compounds : Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors(TEFs). Toxicology, 22, 52-88, 1990
  14. Safe, S. : Detennination of 2,3,7,8-TCDD toxic equivalent factors(TEFs): Support for the use of the in vitro AHH induction assay. Chemosphere, 16, 791-802, 1987 https://doi.org/10.1016/0045-6535(87)90012-9
  15. Tongzhang Zheng, Theodore R. Holford, John Tessari, Susan T. Mayne, Patricia H. Owens, Barbara Ward, Darryl Carter, Peter Boyle, Robert Dubrow, Shannon Archibeque, and Sheila H. Zahm : Breast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls. American Journal of Epidemiology, 152(1), 50-58, 2000 https://doi.org/10.1093/aje/152.1.50
  16. Hawker, D. W. and Connell, D. W. : Octanol-Water Partition Coefficients of polychlorinate Biphenyl Congeners. Environmen. Toxicol. Chen., 22, 382-387, 1988
  17. Ericson : Physical, chemical, commercial, environmental and biological properties, Analytical Chemistry of PCBs, butterworth, Stoneham, MA, Chap 2, 1985
  18. 민선영, 정문호, 이강숙, 노영만, 구정완 : 일부 한국성인 여성들의 혈중 PCBs 농도 및 그 노출요인의 연구. 한국환경위생학회지, 26(2), 97-107, 2000
  19. Laden, F., Meas, L. M., Spiegelman, D., Hankinson, S. E., Willett, W. C., Ireland, K., Wolff, M. S. and Hunter, D. J. : Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environmental Health Perspectives, 107, 75-81, 1999 https://doi.org/10.2307/3434292