Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Analysis of deleterious genes in natural and experimental populations of Drosophila melanogaster

Drosophila melanogaster 자연 및 실험집단내의 유해유전자 분석

  • Published : 2003.06.01
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Abstract

The genetic variabilities of second chromosomes of Drosophila melanogaster concealed in Busan natural and experimental populations have been analyzed by the Cy//Pm method. The experimental population was composed of D. melanogaster which had the lethal-free second chromosome, collected Sasang natural population in 1982. The frequencies of deleterious genes were estimated to be 14.3∼25.4% in Busan natural population and 26.5∼27.2% in experimental population. The allelism rates in lethal genes isolated from the natural and experimental populations were calculated to be about 0.76% and 9.76∼14.17%, respectively. The value of elimination by the frequencies of deleterious genes and allelism rate was 0.0106and the effective population size estimated to be about 430 flies at the 6570 days population.

인가성 종인 노랑 초파리의 제2염색체를 대상으로, 자연집단과 장기 유지시켜온 실험집단의 생존도 관련 유해유전자의 빈도를 조사하였다. 2년간 연속 조사한 부산 일원 자연집단내의 치사 및 반치사를 포함한 유해유전자의 빈도는 약 14.3∼25.4% 정도로서 년도 의존적 불안정 변이를 보인 반면 집단 형성 후 약 6570일과 약 7300일째의 실험집단내의 동 빈도는 약 26.5∼27.2% 정도로서 매우 안정적인 변이를 나타내고 있었다. 치사유전자 보유 염색체를 대상으로한 동좌율 조사에서는 자연집단에서 0.76%의 낮은 비율인데 반하여 실험집단에서는 9.76∼14.17%의 높은 동좌 비율을 보였다. 완전 정상 유전자 보유 계통만으로 형성, 장기 유지시켜온 실험집단내의 치사유전자의 유발과 축적은 세대를 거듭함에 따라 자연 돌연변이에 의해 6570일 현재 약 14.5%의 안정적 빈도를 보여주었다. 집단 내 치사 유전자의 동형접합체화로 인한 집단 내에서의 제거율은 6570일 현재 약 0.0106 정도이며, 이로부터 환산되는 실험집단내의 유효크기는 약 430개체 정도였다.

Keywords

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