Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Wax Guard on Weight, Triglyceride, Leptin and Fat Cell Size in Rats Fed on a High Fat Diet

고지방식이를 섭취시킨 흰쥐에서 동과가 체중, 중성지방, Leptin과 지방세포의 크기에 미치는 영향

  • 강금지 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 임숙자 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 정종길 (동신대학교 한의과 대학) ;
  • 한혜경 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 최성숙 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 김명화 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 권소영 (덕성여자대학교 자연과학대학 식품영양학과)
  • Published : 2003.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the effects of wax gourd on weight, triglyceride, leptin and fat cell size in rats fed a high-fat diet. Male Sprague Dawley rats were fed an experimental diet containing total dietary fat at 40% of calories with wax gourd 0%, 5%, 10% and 15% (w/w) for 4 weeks. Weight gain and triglyceride level fell significantly in the 15% wax gourd group compared to the control group. Epididymal fat pad, abdominal fat and perirenal fat tended to decrease in the 15% wax gourd group. Leptin and free fatty acid level were not significantly different among the groups. Fat cell size significantly decreased in the 10% and 15% wax gourd groups compared to the control group. Weight gain correlated positively with visceral fat masses and the levels of leptin and triglyceride. Fat cell size significantly correlated with visceral fat and leptin level. Therefore, the 15% wax gourd diet substantially reduced weight, triglyceride and fat cell size. (Korean J Nutrition 36(5): 446∼451, 2003)

Keywords

References

  1. National nutrition survey report
  2. National nutrition survey report
  3. National nutrition survey report
  4. Am J Clin Nutr v.67 no.SUP. Mlulti-factorial of obesity:implications for prevention Grundy,S.M.
  5. Annals of Internal Medicine v.103 Complications of obesity Bray,G.A. https://doi.org/10.7326/0003-4819-103-6-1052
  6. Korean J Nutr v.23 no.5 Cause of obesity Huh,K.B.
  7. Nutr Rev v.55 no.5 Obesity Solutions:report of a Meeting Albu,J.;Allison,D.;Boozer,C.N.;Heymsfield,S.;Kissileff,H.;Kretser,A.;Krumhar,K.;Leibel,R.;Nonas,C.;Pi-Sunyer, X.;Vanltalline,T.;Wedral,E. https://doi.org/10.1111/j.1753-4887.1997.tb06469.x
  8. FASEB v.3116 Effect of conjugated linoleic acid on fat pad weights and celluarity in Sprague Dawley and Zucker rats Sisk,M.;Azin,M.J.;Hausman,D.B.;Jewell,D.E.
  9. Cell v.80 The adipocyte:Storage depot or node on the energy information superhighway Flier,J.S. https://doi.org/10.1016/0092-8674(95)90445-X
  10. Nutrition Today v.31 no.4 Leptin:Products of the obese gene Behme,M.T. https://doi.org/10.1097/00017285-199607000-00002
  11. N Engl J Med v.334 Serum immunoreactive-leptin concentrations in normal weight and obese humans Considine,R.V.;Sinha,M.K.;Heiman,M.L.(et al.) https://doi.org/10.1056/NEJM199602013340503
  12. J Nutr v.127 Leptin rapidly lowers food intake and elevates metabolic rats in lean ob/obmice Mistry,A.M.;Swick,A.G.;Romos,D.R.
  13. Master Thesis Effect of total starvation on body composition, serum leptin and lipid profile, and urinary of minerals in women Lee,E.O.
  14. Proc Nutr Soc v.59 no.3 Role of adipose tissue in body-weight regulation:mechanism regulating leptin production and energy blance Havel,P.J. https://doi.org/10.1017/S0029665100000410
  15. Clinical Chemistry Feb v.48 no.2 Markers of triglyceride rich lipoprtein remnant metabolism in vesceral obesity Chan,D.C.;Watts,G.F.;Barrett,P.H.;Mamo,J.C.;Redgrave,T.G.
  16. J Lipid Res Dec v.42 no.12 Increased hepatic VLDL secretion, lipoproteins and SREBP-1 expression in the corpulent JCRLA-CP rat Elam,M.B.;Wilcox, Hg.;Cagen,L.M.;Deng,X.;Raghow,R.;Kumar,P.;Heimberg,M.;Russell,J.C.
  17. J lipid Res v.35 In vivo regulation of lipolysis in humans Coppack,S.W.;Jenson,M.D.;Miles,J.M.
  18. J Clin Invest v.83 no.4 Influence of body fat distribution on free fatty acid metabolism in obesity Jenson,M.D.;Haymond,M.W.;Rizza,R.A.;Cryer, Pe.;Miles,J.M. https://doi.org/10.1172/JCI113997
  19. Metabolism Oct v.43 no.10 Associations between insulin sensitivity and free fatty acid and triglyceride and triglyceride metabolism independent of uncomplicated obesity Bruce,R.;Godsland,I.;Walton,C.;Crock,D.;Wynn,V. https://doi.org/10.1016/0026-0495(94)90222-4
  20. Pulkotnamoo The Encyclopedia of Crops in Korea Song,H.S.
  21. The Encyclopedia of Crops in Korea Ahn,D.G.
  22. Recommended Dietary Allowances for koreans.(7th ed.) Korean Nutrition Society
  23. The Handbook of Oriental Medicine Huh,J.
  24. Korea Food Development institute Report v.10 A study on the weight loss effect of wax gourd and the development of processed food from wax gourd Hong,S.S.;Choi,S.Y.;Cha,S.K.;Kim,H.J.;Park,H.J.;Lee,Y.S.
  25. Nutritional Sciences v.5 no.3 Dietary conjugated linoleic acid did not affect on body fatness,fat cell sizes and leptin levels in Male sprague Dawley rats Kang,K.J.;Kim,K.H.;Park,H.S.
  26. J Cell Physiol v.148 no.3 Dietary fish oil modify adipocytes structure and function Parrish,C.C.;Pathy,D.A.;Parkers,J.G.;Angel,A. https://doi.org/10.1002/jcp.1041480323
  27. Diabetes Jun v.47 no.6 Leptin secretion from subcutaneous and visceral tissue in women Van Harmelen, V.;Reynisdottir,S.;Eriksson,P.;Thorne,A.;Hoffstedt,J.;Lonnqvist,F.;Arner,P. https://doi.org/10.2337/diabetes.47.6.913
  28. Euporean J Endo Nov v.143 no.5 Anthropometric, computed tomography and fat cell data in obese population:relationship with insulin, leptin, tumor necrosis factor-alpha, sex homone-binding globulin and sex hormones Garaulwt,M.;Perex-Llamas, F.;fuente,T.;Zamora,S.;Tebar,F.J.