Nutritional Sciences
- 제6권1호
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- Pages.25-30
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- 2003
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- 1229-232X(pISSN)
Regulation of cyclooxygenase-2 and mapkinases by isoflavones in ovariectomized and estrogen-supplemented mature female rats fed a high fat-high cholesterol diet
- Shin, Jang-In (Department of Food and Nutrition, Human University) ;
- Park, Ock-Jin (Department of Food and Nutrition, Human University)
- 발행 : 2003.02.01
초록
The effects of soy-isoflavones, which are phytoestrogens derived from plants with a flavonoid structure, on cyclooxygenase -2 (COX-2) expression, PGE2 production, and mapkinases expression, were investigated in experimentally-induced atherogenic rats by feeding a high fat-high cholesterol diet. Female Sprague-Dawley rats were bilaterally ovariectomized; sham-operated animals were used as controls. Three weeks later, the animals were randomized to the following treatments for an eight-week experimental period: 17
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