Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Phase Behaviors of Binary Protein Systems: Consideration of Structural Effects

  • Kim, Sang-Gon (Division of Chemical Engineering, Hanyang University) ;
  • Kong, Sung-Ho (Division of Chemical Engineering, Hanyang University) ;
  • Bae, Young-Chan (Division of Chemical Engineering, Hanyang University) ;
  • Kim, Sun-Joon (Department of Environmental Geosystem Engineering, Hanyang University)
  • Published : 2003.08.31
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Abstract

A molecular-thermodynamic model to describe the salt-induced protein precipitation is developed based on the perturbation theory. We employed the modified perturbed hard-sphere-chain (PHSC) equation of state for copolymer mixtures to take into account the pre-aggregation effect among protein particles. Hypothetical pressure-composition diagrams are computed with various size differences and salt concentrations. The precipitation behaviors are also studied for various types of pre-aggregation effect for the given systems.

Keywords

References

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