Journal of Gastric Cancer
- 제3권1호
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- Pages.38-43
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- 2003
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- 2093-582X(pISSN)
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- 2093-5641(eISSN)
한국인 위암에서 Caspase 2 단백 발현 양상
Expression Pattern of Caspase 2 in Korean Gastric Cancers
- 김창재 (가톨릭대학교 의과대학 병리학교실) ;
- 박직영 (가톨릭대학교 의과대학 병리학교실) ;
- 이종흔 (가톨릭대학교 의과대학 병리학교실) ;
- 조용구 (가톨릭대학교 의과대학 병리학교실) ;
- 이종우 (가톨릭대학교 의과대학 병리학교실) ;
- 송영화 (가톨릭대학교 의과대학 병리학교실) ;
- 김영실 (가톨릭대학교 의과대학 병리학교실) ;
- 박조현 (가톨릭대학교 의과대학 외과학교실) ;
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남석우
(가톨릭대학교 의과대학 병리학교실) ;
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이석형
(가톨릭대학교 의과대학 병리학교실) ;
-
유남진
(가톨릭대학교 의과대학 병리학교실) ;
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박원상
(가톨릭대학교 의과대학 병리학교실) ;
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이정용
(가톨릭대학교 의과대학 병리학교실)
- Kim, Chang-Jae (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Park, Jik-Young (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Lee, Jong-Heun (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Cho, Young-Gu (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Lee, Jong-Woo (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Song, Young-Hwa (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Kim, Young-Sil (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
- Park, Cho, Hyun (Departments of Surgery, Medical Research Center, College of Medicine, The Catholic University of Korea) ;
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Nam, Suk-Woo
(Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
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Lee, Sug-Hyung
(Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
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Yoo-Nam-Jin
(Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
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Park, Won-Sang
(Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
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Lee, Jung, Young
(Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea)
- 발행 : 2003.03.01
초록
Purpose: Caspase 2, a member of the family of ICE-like proteases, is activated by the Fas pathway and induces apoptosis by triggering the caspase cascade. The purpose of this study was to determine whether the expression pattern of caspase 2 might be associated with gastric cancer development and if so, to determine to which pathologic parameter it is linked. Materials and Methods: For the construction of the gastric cancer tissue microarray, 78 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of caspase 2 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. Results: Caspase 2 was expressed on superficial and foveolar epithelial cells and lymphocytes in the gastric mucosa, mainly in cytoplasm. We found loss of caspase 2 expression in 41 (