한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제13권1호
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- Pages.1-4
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- 2003
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
신장이식 후 Cyclosporine 혈중농도와 거부반응 및 신독성과의 관계
The Relationship between Cyclosporine Trough Concentrations and Allograft Rejection and Renal Toxicity after Renal Transplantation
- Choi, Soo An (Department of Pharmacy, Seoul National University Hospital) ;
- Suh, Ok Kyung (College of Pharmacy, Seoul National University) ;
- Lee, Byung Ku (Department of Pharmacy, Seoul National University Hospital) ;
- Son, In Ja (Department of Pharmacy, Seoul National University Hospital) ;
- Shin, Wan Gyoon (College of Pharmacy, Seoul National University)
- 발행 : 2003.06.01
초록
Cyclosporine (CsA) has become well established as a potent immunosuppressive agent in the renal transplantation. However, therapy is complicated by large intraindividual and interindividual variability in pharmacokinetics of CsA and frequent undesirable clinical outcomes such as graft rejection and nephrotoxicity. The objective of this study was to determine the CsA trough blood concentrations that were associated with acute graft rejection and renal toxicity in renal transplant patients. Also, the ability of the current recommendation of therapeutic range for CsA to prevent graft rejections and CsA-associated renal toxicity was assessed. The clinical courses of the patients on CsA as an immusuppressive agent for preventing the graft rejection with renal ransplantation performed at Seoul National University Hospital from January 1995 to September 1998 were retrospectively reviewed. Total of 78 patients were included and three of them were retransplantation cases. Twenty-two acute episodes of rejection were identified, but only 16 episodes were clinically significant. Of these all the episodes occurred during the first month after transplantation except one. Mean daily doses of CsA were
키워드