한약(韓藥)의 면역조절(免疫調節) 작용(作用)을 통(通)한 종양치료(腫瘍治療)에 대(對)한 연구(硏究)

The effects of immune activating herbs on the anti-tumor activity

  • 이정수 (대전대학교 부속한방병원 동서암센터) ;
  • 이연월 (대전대학교 부속한방병원 동서암센터) ;
  • 조정효 (대전대학교 부속한방병원 동서암센터) ;
  • 손창규 (대전대학교 부속한방병원 동서암센터) ;
  • 유화승 (대전대학교 부속한방병원 동서암센터) ;
  • 조종관 (대전대학교 부속한방병원 동서암센터)
  • Lee, Jung-Soo (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Lee, Yeon-Weol (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Cho, Jung-Hyo (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Son, Chang-Kyu (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Hwa-Seung (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Cho, Chong-Kwan (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University)
  • 발행 : 2003.12.30

초록

The researches for tumor and the developments for new anti-tumor medicine are being continuously developed in the oriental as well as the west. The principles therapy of anti-tumor activity was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils. But the major clinical features of tumor was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distinction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. In clinical study and experimental study, the effects of oriental medicine could be summarized as three that were decreasing toxicity of chemo-therapy, directly suppressing and killing cancerous cell and increasing chemo-effect through preventing metastasis. Improving organic immunity with oriental medicine could be summarized as five that were promoting phagocytosis of macrophage, inducing interferon, promoting formation of immnoglobulin, increasing number of T-cell and promoting transformation of lymphocyte. It is suggested that effective use of immune activating herbs inhibited metastasis and decreased recurrence and then we were able to expect increasing survival rate and improving clinical symptoms and quality of life(QOL) of tumor patients.

키워드

참고문헌

  1. 腫瘤辨病專方治療 凌昌全
  2. 上海中醫藥雜誌 v.7 惡性腫瘤中醫調理四法 儲水흠
  3. 浙江中醫學院學報 v.17 no.4 扶正法在腫瘤治療中的臨床運用 陳炳旗
  4. 中醫雜誌 v.28 no.5 在惡性腫瘤治療中如何合理應用活血化瘀藥物 邱佳信
  5. 上海中醫藥雜誌 v.4 治癌芻議 陳紹東
  6. 精校黃帝內經素問 洪元植(編)
  7. 癌東西의 綜合治療 문구;정병학;김병주
  8. 韓方臨床腫瘍學 趙鍾寬
  9. Current opinion in immunology v.12 Cancer. Allison, J.P.
  10. 대전대논문집 v.9 no.2 암의 면역치료에 대한 고찰 박종학
  11. 혜화의학 v.10 no.2 암의 발생과 면역에 대한 고찰 조정효
  12. 면역의 의미론 타다 토미오
  13. Current opinion in immunology v.12 Cancer Allison, J.P.
  14. Immunology v.5 Roitt, I.;Brostoff, J.;Male, D.
  15. Current opinion in immunology v.10 The role of $CD_4+T$cell responses in antitumor immunity. Pardoll, D.M.;Topalian
  16. Current opinion in immunology v.6 Tumor immunotherapy: the tumor cell as an antigen-presenting cell Rosenberg, S.O.
  17. Current opinion in immunology v.13 Immunology against cancer. Houghton, A.N.;Gold, J.S.;Blachere, N.E.
  18. Immunology Today v.20 What is the real role of CD40 in cancer immuntherapy Costello, R.T.;Gastaut, J.A.;Olive, D.
  19. Current opinion in immunology v.10 Tumor expression of fas ligand (CD95L) and the consequences. Walker, P.R.;Saas, P.;Dietrich, P.Y.
  20. Current opinion in immunology v.12 The dendritic cell and human cancer vaccines. Dallal, M.R.;Lotze, M.T.
  21. 東洋醫學 v.12 no.1 免疫에 關한 東洋醫學的 考察 趙鍾寬
  22. 衛生寶鑑 羅天益
  23. 醫宗必讀 李中梓
  24. 中國中醫基礎醫學雜誌 v.6 no.3 腫瘍虛證及扶正培本治療的現代免疫機制硏究[J] 花寶金;朴炳奎
  25. 中藥免疫藥理學[M] 周金黃
  26. 中草藥 v.20 no.1 中藥多糖抗腫瘤硏究進展[J] 朱德志;鄭顯明
  27. 中藥免疫調節作用在抗腫瘤中應用硏究 v.19 no.1 朱芳林
  28. 中國食品與衛生雜誌 v.12 黃芪的免疫調節作用硏究進展[J] 王紅梅;姚小曼
  29. IntImmunopharmacol v.5 no.17 lentinan augimets, skin reaction induced by bradgkinin. 2is Crrelnion with reascallar dilation and hemorrhage responses. and antitumor activities[J] NamikiFi, S.;Kikuchi, R.;Tomoko, K.(et al.)
  30. 藥學學報 v.31 no.2 香고多糖的免疫調節作用[J] 王格林;林志彬(等)
  31. 中國新藥雜誌 v.8 no.11 中藥免疫調節劑的硏究和開發[J] 田庚云
  32. Planna Med v.59 Inibition of autochthonous tumor by ethanol insoluble fraction from panax ginseng as an immunomodulator[J] Yun, Y.S.;Lee, Y.S.;Jo, S.K.
  33. 中國中西醫結合雜誌 v.13 no.12 人蔘莖葉總조試對58例急性非淋巴細胞白血病細胞誘導分化作用[J] 易永林;李薇;?秀智
  34. Pharmazie v.52 no.12 Immunomodulatory and antitumoral effects of triterpenoid saponins [J] Plohmann, B.;BaDer, G.;Hiller, K.(et al.)
  35. Pharmazie v.51 no.6 Cytotoxilicity oftritepenoid saponins. Partl : Actiiiiivites against tumor cells in vitro and hemdytical index[J] Bader, G.;Plohmann, B.;BaDer, G.;Hiller, K.(et al)
  36. 上海免疫學雜誌 v.13 no.4 胎盤免疫調節因子理化性質及生物學活性的實驗硏究[J] 李思善;董방全;楊琨(等)
  37. 中國中西醫 結合雜誌 v.12 no.8 胎盤因子對機體細胞免疫功能的調節作用[J] 楊琨;舒翠玲;趙寧(等)
  38. 前衛醫學雜誌 v.8 no.1 胎盤免疫調節태治療腫瘍100例療效與免疫功能觀察[J] 彭立義;楊道理;齊法蓮(等)
  39. 新鄕醫學院學報 v.3 no.2 胎盤免疫調節태抑留效應的硏究[J] 풍慧根;韓金紅;盧光榮(等)
  40. 癌變$\cdot$畸變$\cdot$突變 v.10 no.3 胎盤免疫調節多태遺傳毒性和抗突變作用的硏究[J] 풍慧根;李廷蘭;劉明林(等)
  41. 江蘇中醫 v.17 no.9 國産香고多糖治療癌證患者 NK活性的影響[J] 王蘇;周振英;潘良熹(等)
  42. 中國中西醫結合雜誌 v.18 no.7 康菜特的肺癌切除術後肺氣虛及免疫功能低下的患者進行了的觀察[J] 王?富;馬長金;王秀淸
  43. 廣西醫學 v.10 no.1 胎盤免疫調節因子治療惡性腫瘤 313例的 臨床硏究 [J] 梁積恒;張麗生