Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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BONE FORMATION USING INJECTABLE TISSUE-ENGINEERING MATERIALS

주사형 조직공학재료를 이용한 골형성

  • Choi, Byung-Ho (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Park, Dong-Joon (Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine) ;
  • Zhu, Shi-Jiang (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Huh, Jin-Young (Department of Dentistry, Kangneung Asan Hospital, University of Ulsan) ;
  • Kim, Byung-Young (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Lee, Seoung-Ho (Department of Periodontology, College of Medicine, Ewha Womens University)
  • 최병호 (연세대학교 치과대학 구강악안면외과학교실(원주기독병원)) ;
  • 박동준 (연세대학교 원주의과대학 이비인후과학교실) ;
  • 주석강 (연세대학교 치과대학 구강악안면외과학교실(원주기독병원)) ;
  • 허진영 (울산대학교 의과대학 강릉아산병원 치과) ;
  • 김병용 (연세대학교 치과대학 구강악안면외과학교실(원주기독병원)) ;
  • 이승호 (이화여자대학교 의과대학 치주과)
  • Published : 2003.12.31
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Abstract

Aim : Several injectable materials have been used in the application of osteogenic bone substitute; however, nothing has won universal acceptance. This study was performed to investigate whether chitosan-alginate gel/MSCs/BMP-2 composites are potentially injectable materials for new bone formation. Material and Methods : The composites were injected into the subcutaneous space on the dorsum of the nude mouse to investigate whether new bone would be tissue engineered in the mouse. The composites were examined histologically over a 12-week period. Results : The composites implanted in the mouse were able to tissue engineer new bone, and the newly formed bone consisted of trabecular bone and calcified bone matrix. Conclusions : The present study shows that chitosan-alginate gel/MSCs/BMP-2 composites have the potential to become real injectable materials for new bone formation.

Keywords

References

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